睡眠剥夺中感觉运动皮层和视觉皮层神经活动及警觉水平的改变（英文）  

Alteration of Neural Activity in The Sensorimotor and Visual Cortices and Vigilance Level During Sleep Deprivation

作　　者：张岱 左真涛[3,4,5] 饶衡毅 范勇 ZHANG Dai;ZUO Zhen-Tao;RAO Heng-Yi;FAN Yong(National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences;University of Chinese Academy of Sciences,Beijing 100049,China;State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China;CAS Center for Excellence in Brain and Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;Department of Neurology,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA;Department of Radiology,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA)

机构地区：[1]中国科学院自动化研究所模式识别国家重点实验室,北京100190 [2]中国科学院大学,北京100049 [3]中国科学院生物物理研究所脑与认知科学统计重点实验室,北京100101 [4]中国科学院大学中丹学院,北京100049 [5]中国科学院脑科学与智能技术卓越创新中心,上海200031 [6]Department of Neurology,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA [7]Department of Radiology,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA

出　　处：《生物化学与生物物理进展》2020年第2期139-156,共18页Progress In Biochemistry and Biophysics

基　　金：supported by grants from National Basic Research Program of China(2015CB856400,2015CB351701);The National Natural Science Foundation of China(81501158,31730039,31671133);The National Major Scientific Instruments and Equipment Development Project(ZDYZ2015-2);The Chinese Academy of Sciences Strategic Priority Research Program B grants(XDBS32000000)~~

摘　　要：在睡眠剥夺(sleep deprivation,SD)过程中,人类大脑的神经活动和警觉水平如何受到影响,尤其是感觉运动和视觉系统,目前仍是研究的热点.静息状态功能磁共振成像(resting state functional magnetic resonance imaging,rf MRI)作为一种反映人脑自发活动的非侵入式成像技术,在睡眠剥夺的研究中得到了广泛应用.本研究采用9次重复rf MRI和心理运动警觉任务(psychomotor vigilance task,PVT),以探索23名志愿者在整个36 h的睡眠剥夺过程中神经活动和警觉水平的变化.采用基于PVT的平均反应时间(mean reaction time,MRT)和失效率(lapses ratio,LR)评估警觉水平的变化;采用基于rf MRI的区域同质性(region homogeneity,Re Ho)和低频波动幅度(amplitude of low frequency fluctuation,ALFF)评估大脑神经活动变化.结果表明,感觉运动网络(sensorimotor network,SMN)和视觉区域(visual network,VN)是受到睡眠剥夺影响最严重的区域.我们采用组独立成分分析(group independent component analysis,GICA)将视觉相关区域划分为视觉Ⅰ区、视觉Ⅱ区、视觉关联区,并从解剖自动标记(anatomical automatic labeling,AAL)模板中提取运动感觉相关区域,包括中央前/中央后回、中央旁小叶和辅助运动区.研究发现,睡眠剥夺后16~30 h脑神经活动及警惕性下降.采用2×3重复测量方差分析,探讨睡眠压力、昼夜节律及其交互作用对感觉运动相关和视觉相关脑区神经活动的影响.观察到睡眠压力与交互作用对感觉运动相关区域和视觉相关区域有显著影响.采用皮尔逊相关系数评估警觉水平变化与感觉运动相关和视觉相关脑区神经活动变化的关系.睡眠剥夺期间所有感觉运动相关区域的神经活动变化与警觉变化均存在显著的相关关系.研究结果证实,睡眠剥夺从第一天24:00开始改变SMN和VN的警戒水平和神经活动,睡眠压力和昼夜节律在睡眠剥夺期间调节SMN和VN的神经活动.此外,昼夜节律�The mechanism underlying the alteration of neural activity in the human brain and the vigilance level during sleep deprivation(SD)remains a subject of ongoing investigation,particularly with regard to the sensorimotor and visual systems.Restingstate functional magnetic resonance imaging(rf MRI),a noninvasive imaging technology reflecting spontaneous activity of the human brain,is widely used in SD research.In the present study,nine repeated rf MRI sessions followed by a psychomotor vigilance task(PVT)were used to explore the alteration of neural activity and vigilance level during 36 h of SD in 23 volunteers.Mean reaction time(MRT)and lapse ratio(LR)based on PVT were measured to assess variation in vigilance level.The sensorimotor network(SMN)and visual network(VN)are the most vulnerable areas after obtaining SD measures from Re Ho(regional homogeneity)and ALFF(amplitude of low-frequency fluctuation)based on rf MRI.Group-ICA was used to parcellate the visualrelated regions into visual areaⅠ,visual areaⅡ,and the visual association area.Sensorimotor-related regions,including the bilateral precentral/postcentral gyrus,the bilateral paracentral lobule,and the supplementary motor area(SMA),were extracted from the anatomical automatic labeling(AAL)templates.Brain neural activity and vigilance level were deteriorated at 16-30 h of SD.A2×3 repeated-measures ANOVA was used to explore the effects of sleep pressure and circadian rhythm and their interaction on neural activities of sensorimotor-related and visual-related regions.Significant effects of sleep pressure and interaction on all sensorimotor-related and visual-related regions were observed.Pearson’s correlation coefficients were used to explore the relationships between variation in vigilance level and alteration in brain neural activities of sensorimotor-related and visual-related regions.Significant correlations were observed between the neural activities of all sensorimotor-related regions and variation in vigilance during SD.Our results confirmed that SD

关 键 词：静息态功能磁共振成像 睡眠剥夺 感觉运动皮层 视觉皮层 大脑神经活动 

分 类 号：B842.2[哲学宗教—基础心理学] R445.2[哲学宗教—心理学]