食管基底细胞样鳞状细胞癌11例诊治分析  

Diagnosis and treatment of 11 cases of basaloid squamous cell carcinoma of the esophagus

作　　者：王福栋 翁鸢 耿纪群 朱军 Wang Fudong;Weng Yuan;Geng Jiqun;Zhu Jun(Department of Cardiothoracic Surgery,the Affiliated Hospital of Jiangnan University,the Fourth People’s Hospital of Wuxi,Wuxi 214000,China)

机构地区：[1]江南大学附属医院(无锡市第四人民医院)胸心外科,江苏无锡214000

出　　处：《中国实用医刊》2019年第23期48-51,共4页Chinese Journal of Practical Medicine

摘　　要：目的研究食管基底细胞样鳞状细胞癌(BSCCE)的临床病例特点、诊治方法、分子病理学机制及预后。方法回顾性分析江南大学附属医院2014—2017年收治的11例BSCCE患者的临床资料和生存随访资料。结果11例BSCCE患者中男8例,女3例,年龄57~79岁,平均68.5岁;食管上段1例,中段9例,下段1例;11例患者均为中低分化,且绝大多数患者Ki-67指数较高(Ki-67>80%)。至随访截止日期,共随访8~48个月,7例患者存活,4例患者死亡(生存时间24~48个月)。结论BSCCE是一种恶性程度高并具有侵袭性的罕见肿瘤,大多数患者分化程度较低,预后较差。BSCCE术前诊断较为困难,其最佳治疗方案有待进一步研究证实。Objective To study the clinical features,diagnosis and treatment,molecular pathology and prognosis of basaloid squamous cell carcinoma of the esophagus(BSCCE).Methods The clinical data and survival follow-up data of 11 patients with BSCCE admitted to the Affiliated Hospital of Jiangnan University from 2014 to 2017 were retrospectively analyzed.Results There were 8 males and 3 females in 11 BSCCE patients,aged 57 to 79 years,with an average of 68.5 years.Tumor location was upper esophagus in 1 case,middle esophagus in 9 cases and lower esophagus in 1 case.All the 11 patients were moderately or poorly differentiated,and the Ki-67 index was higher(Ki-67>80%)in most patients.Up to the deadline of follow-up,patients were followed up for 8 to 48 months.Seven patients survived and four died(survival time was 24 to 48 months).Conclusions BSCCE is a malignant and aggressive tumor,and most patients have a lower degree of differentiation and poor prognoses.Preoperative diagnosis of BSCCE is difficult,and the best treatment plan is to be confirmed by further research.

关 键 词：食管基底细胞样鳞状细胞癌 诊断 分子病理学 预后 

分 类 号：R735.1[医药卫生—肿瘤]