中性粒细胞参数在鉴别急性髓细胞白血病和急性淋巴细胞白血病中的价值  

Clinical value of neutrophil parameters in identifying acute myeloid leukemia and acute lymphoblastic leukemia

作　　者：陈碧[1] 陈小剑[1] 蒋伟燕[1] 江明华[1] CHEN Bi;CHEN Xiao-jian;JIANG Wei-yan;JIANG Ming-hua(Clinical Ijiboratoryy the 2nd Affiliated Hospital&Yuying Childrens Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325027,China)

机构地区：[1]温州医科大学附属第二医院医学检验中心

出　　处：《中国卫生检验杂志》2019年第24期2981-2983,共3页Chinese Journal of Health Laboratory Technology

基　　金：温州市科技局公益项目(Y20160520)

摘　　要：目的探讨Sysmex XE-5000自动化血液分析仪的中性粒细胞参数(NEUT-X中性粒细胞的侧向散射光、NEUT-Y中性粒细胞荧光)在鉴别急性髓细胞白血病和急性淋巴细胞白血病中的应用价值。方法收集急性白血病初发患者87例(急性白血病组)的外周血液样本,其中62例为急性髓细胞白血病组,25例为急性淋巴细胞白血病组,另收集80例健康体检者(对照组)的外周血样本,用Sysmex XE-5000上对其NEUT-X、NEUT-Y参数进行检测。结果急性白血病组与对照组相比,NEUT-X、NEUT-Y 2个参数结果均有降低,差异有统计学意义(P <0. 05)。急性髓细胞白血病组NEUT-X、NEUT-Y值均较对照组降低,差异有统计学意义(P <0. 05);急性髓细胞白血病组NEUT-X值与急性淋巴细胞白血病组NEUT-X值比较降低,差异有统计学意义(P <0. 05),NEUT-Y值差异无统计学意义。结论中性粒细胞参数NEUT-X、NEUT-Y值对急性白血病的鉴别有价值;NEUT-X值对鉴别急性髓细胞白血病与急性淋巴细胞白血病的价值更大。Objective To investigate the clinical value of NEUT-X,NEUT-Y parameters in differentiating acute myelogenous leukemia and acute lymphoblastic leukemia. Methods The neutrophil NEUT parameters( NEUT-X,NEUT-Y) of peripheral blood samples from 62 cases of acute myelogenous leukemia,25 cases of acute lymphocytic leukemia and 80 healthy individuals were analyzed on Sysmex XE-5000 hematology analyzer. Results There are significant decreases in the neutrophil NEUT parameters( NEUT-X,NEUT-Y) from the acute leukemia group compared with control group,and the differences were statistically significant( P < 0. 05). The NEUT-X and NEUT-Y values in the acute myeloid leukemia group decreased compared with the control group,with the differences statistically significant( P < 0. 05). NEUT-X decreased in the acute myeloid leukemia group compared with the acute lymphocytic leukemia group,and the difference was statistically significant( P < 0. 05),but there was no statistical significance on the differences of NEUT-Y. Conclusion NEUT-X and NEUT-Y parameters of neutrophils are valuable for the differentiation between acute leukemia and healthy individuals. The value of NEUT-X may be more valuable in differentiating acute myeloid leukemia from acute lymphoblastic leukemia.

关 键 词：血液细胞分析仪 血液恶性肿瘤 中性粒细胞参数 白血病 

分 类 号：R733.71[医药卫生—肿瘤]