血小板和淋巴细胞的比值、中性粒细胞和淋巴细胞的比值与非小细胞肺癌的临床病理学关系及预后效果研究  

Clinicopathological relationship between PLR,NLR and non-small cell lung cancer and the research on prognostic efficacy

作　　者：童晶涛 张欢乐[1] 郑璐[1] 许权[1] 杨梓汝 陆妙珍[1] TONG Jing-tao;ZHANG Huan-le;ZHENG Lu;XU Quan;YANG Zi-ru;LU Miao-zhen(Radiotherapy Department,Ningbo Medical C enter Lihuili Hospital,Ningbo,Zhejiang 315040,China)

机构地区：[1]宁波市医疗中心李惠利医院放疗科

出　　处：《中国卫生检验杂志》2019年第24期3020-3023,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的研究血小板和淋巴细胞的比值(PLR)、中性粒细胞和淋巴细胞的比值(NLR)与非小细胞肺癌患者的临床病理学关系及预后效果。方法选择2017年1月-2018年8月本院138例原发性非小细胞肺癌患者,分析临床病理学参数和PLR、NLR关系,探讨PLR、NLR和患者预后相关性。结果 PLR与非小细胞肺癌患者的PS评分存在相关性(P <0. 05);PLR与非小细胞肺癌患者的性别、年龄、吸烟、肿瘤大小、肿瘤分化程度、临床分期、T分期、淋巴结转移无相关性(P> 0. 05);NLR与非小细胞肺癌患者的肿瘤分化程度、临床分期、T分期存在相关性(P <0. 05);低NLR组患者的生存时间高于高NLR组(P <0. 05);多因素分析结果显示,PLR、NLR及PS评分为影响非小细胞肺癌患者生存的独立危险因素(P <0. 05)。结论 PLR、NLR能作为预测非小细胞肺癌病情进展、预后的独立因素,即水平增高和病情进展存在相关性。Objective To study the clinicopathological relationship and prognosis between the ratio of platelet to lymphocyte( PLR),neutrophil and lymphocyte ratio( NLR) and non-small cell lung cancer. Methods 138 cases of patients with primary non-small cell lung cancer were enrolled in our hospital from January 2017 to August 2018. The relationship between clinicopathological parameters and PLR,NLR was analyzed to investigate the correlation between PLR,NLR and prognosis.Results There was correlation between PS scores in patients with PLR and non-small cell lung cancer( P < 0. 05). There was no correlation between PLR and gender,age,smoking,tumor size,tumor differentiation,clinical stage,T stage,and lymph node metastasis in patients with non-small cell lung cancer( P > 0. 05). There was correlation between NLR and the degree of tumor differentiation,clinical stage and T stage in patients with non-small cell lung cancer( P < 0. 05). The survival time of patients with low NLR group was higher than that of high NLR group( P < 0. 05). Multivariate analysis showed that PLR,NLR,and PS scores were independent risk factors for the survival in patients with non-small cell lung cancer.Conclusion PLR and NLR can be used as independent factors in predicting the progression and prognosis of non-small cell lung cancer. There is a correlation between increased levels of PLR and NLR and progression.

关 键 词：血小板和淋巴细胞的比值 中性粒细胞和淋巴细胞的比值 非小细胞肺癌 临床病理学 预后 

分 类 号：R734.2[医药卫生—肿瘤]