口腔微生物与食管癌关系的研究进展  

Research progress on the relationship between oral microorganisms and esophageal cancer

作　　者：王春萌 洪丽华[1] 王渝 张志民[1] WANG Chun⁃meng;HONG Lihua;WANG Yu;ZHANG Zhimin(Department of Endodontics,School and Hospital of Stomatology,Jilin University,Changchun 130021,China;Department of Gastroenterology,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院牙体牙髓病科,吉林长春130021 [2]吉林大学第一医院内镜中心,吉林长春130021

出　　处：《口腔疾病防治》2020年第3期195-199,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：吉林省自然科学基金项目(3D516M313431)

摘　　要：食管癌作为高致死率的消化系统恶性肿瘤之一,其致病因素一直是学者们研究的热点,近来研究发现食管中微生物及其代谢产物也可能成为致病因素之一。口腔和食管由于其在解剖结构上的连续性,二者在菌群组成上也有一定的相关性。近年来,不断有学者就口腔微生物与食管癌的关系进行研究,以期通过监测口腔微生物的变化,更有效的诊断和治疗食管癌。本文将口腔微生物与食管癌的研究现状进行综述。文献综述结果表明,在食管癌发生及发展过程中,食管中细菌多样性受到口腔菌群影响。其中,包括牙龈卟啉单胞菌、福塞坦氏菌和齿垢密螺旋体在内的牙周红色复合体,草绿色链球菌、具核梭杆菌等常见的口腔微生物都与食管癌的发生发展具有一定程度的联系。目前,对于微生物与食管癌机制的研究较少,但学者们发现食管中革兰氏阴性细菌产物脂多糖和内毒素可能参与宿主固有免疫反应,相关作用机制还需要进一步研究,以寻找新的监测和治疗靶点。Esophageal cancer is one of the most lethal digestive system cancers, and its pathogenic factors have always been the focus of research. Recently, it has been found that microorganisms and their metabolites in the esophagus may also represent one of the pathogenic factors. Because of their continuity in anatomical structure, the oral cavity and esophagus have a certain correlation in terms of the composition of flora. In recent years, many scholars have studied the relationship between oral microorganisms and esophageal cancer to monitor changes in oral microorganisms as well as to diagnose and treat esophageal cancer more effectively. In this paper, the research status of oral microorganisms and esophageal cancer was reviewed. The results of the literature review show that the diversity of bacteria in the esophagus is affected by oral flora in terms of the occurrence and development of esophageal cancer. Among these bacteria,the periodontal red complex, which includes Porphyromonas gingivalis, forsythia and Treponema dentata, as well as common oral microorganisms, such as Streptococcus viridis and Fusobacterium nucleatum, are all related to the occurrence and development of esophageal cancer to a certain extent. At present, there are few studies on the mechanism of microorganisms and esophageal cancer, but scholars have found that lipopolysaccharides and endotoxins, the products of Gramnegative bacteria in the esophagus, may participate in the innate immune response of the host, and the relevant mechanism of action needs further study in order to find new targets for monitoring and treatment.

关 键 词：食管癌 菌群 牙周红色复合体 牙龈卟啉单胞菌 福塞坦氏菌 齿垢密螺旋体 具核梭杆菌 草绿色链球菌 

分 类 号：R78[医药卫生—口腔医学]