肺腺癌组织中Trophinin 相关蛋白的表达及临床病理联系  

Expressions and clinicopathological relationships of trophinin associated protein in lung adenocarcinoma

作　　者：雷宇[1] 黄山[2] 路燕 Lei Yu;Huang Shan;Lu Yan(Dept of Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Dept of Pathology,The Second Affiliated Hospital of Anhui Medical University,Hefei 230601;Dept of Gastroenterology,The Second Affiliated Hospital of Anhui Medical University,Hefei 230601)

机构地区：[1]安徽医科大学第一附属医院肿瘤内科,合肥230022 [2]安徽医科大学第二附属医院病理科,合肥230601 [3]安徽医科大学第二附属医院消化内科,合肥230601

出　　处：《安徽医科大学学报》2020年第1期118-123,共6页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金青年科学基金项目(编号:1808085QH232);国家自然科学基金青年科学基金项目(编号:81800524)

摘　　要：目的探讨肺腺癌组织中Trophinin相关蛋白(TROAP)的表达及临床病理联系。方法通过对多个公共数据库的发掘,分析TROAP的差异表达及其对患者预后的影响。免疫组化检测30例肺腺癌患者肿瘤-癌旁配对组织中TROAP的表达,分析其表达差异以及与患者临床病理特征(性别、年龄、TNM分期、Ki-67表达、有无吸烟史、有无胸腔积液、EGFR突变状态)之间的联系。结果大数据分析提示该基因在肺癌等多种实体瘤中高表达。高表达的肺腺癌患者生存期明显缩短。免疫组化染色提示该基因在肺腺癌患者肿瘤组织中的表达[组织学得分(H-Score)=150.00(100.00,180.00)]明显高于癌旁正常肺组织[H-Score=80.00(58.75,125.00)],差异有统计学意义(P=2.69×10-5)。此外,TROAP基因的表达在不同疾病分期(P=0.039)、是否存在远处转移(P=0.031)以及不同Ki-67表达(P=0.006)中存在显著差异。结论TROAP基因可能在肺腺癌的发生、发展以及侵袭和转移过程中发挥重要作用,可以作为潜在的发病、治疗以及判断预后的生物标志物。Objective To investigate the expressions and clinicopathological relationships of Trophinin associated protein(TROAP)in lung adenocarcinoma.Methods The differential expression of TROAP and its impact on patients prognosis were analyzed by exploring multiple public databases.Immunohistochemical staining was used to detect the histological score(H-Score)of TROAP in 30 patients with lung adenocarcinoma.The differences in expression and clinicopathological features(sex,age,TNM stage,Ki-67 level,smoking history,pleural effusion and Epidermal Growth Factor Receptor(EGFR)mutation status)were analyzed.Results Database analysis suggested that this gene was highly expressed in various solid tumors such as lung cancer.The survival of lung adenocarcinoma patients with high expression of TROAP gene was significantly shortened.Immunohistochemical staining suggested that the expression of this gene in tumor tissues of lung adenocarcinoma patients[H-Score(Histological Score)=150.00(100.00,180.00)]was significantly higher than that in adjacent normal lung tissues[H-Score=80.00(58.75,125.00)].This difference had statistical significance(P=2.69×10-5).In addition,the expression of TROAP gene expression was significantly different in disease stages(P=0.039),whether there was distant metastasis(P=0.031)and different Ki-67 expressions(P=0.006).Conclusion TROAP may play an important role in the tumorigenesis,development,invasion and metastasis of lung adenocarcinoma.It could be used as a potential biomarker for pathogenesis,treatment and prognosis.

关 键 词：肺腺癌 TROAP 表达 临床特征 

分 类 号：R734.1[医药卫生—肿瘤]