霸王鞭内生真菌中的一个新的酚类化合物  

A new phenolic component from endophytic fungus of Euphorbia royleana Boss

作　　者：祝丽君 吴善超 陈彦君 董淼 周敏[1] 陈毅坚[1] 叶艳青[1] Zhu Li-jun;Wu shan-chao;Chen Yan-jun;Dong Miao;Zhou Min;Chen Yi-jian;Ye Yan-qing(Key Laboratory of Ministry of Education,National Committee of Civil and Pharmaceutical Resources Chemistry,Yunnan University for Nationalities,Kunming 650500,China)

机构地区：[1]云南民族大学民药资源化学国家民委-教育部重点实验室

出　　处：《云南大学学报（自然科学版）》2020年第1期156-159,共4页Journal of Yunnan University(Natural Sciences Edition)

基　　金：国家自然科学基金(31560099,31860099)

摘　　要：对霸王鞭内生真菌烟曲霉的次生代谢产物进行研究,以期发现新的化合物.利用MCI-gel树脂、硅胶及PR-HPLC等多种色谱技术进行分离纯化,利用质谱、核磁共振(NMR)、紫外以及旋光对化合物进行鉴定.从霸王鞭内生真菌烟曲霉中分离鉴定获得3个化合物(1~3).其中化合物1为一个新的酚类成分,命名为methyl 4-(3,4-dihydroxyphenyl)-2-hydroxy-4-oxobutanoate(1).The secondary metabolites of the endophytic fungus Aspergillus fumigatus derived from Euphorbia royleana was studied.Silica gel column chromatography,Sephadex LH-20 gel and liquid chromatography were used to separate and purify of Aspergillus fumigatus.The compounds were identified according to their physical and chemical properties and spectroscopic data.Three compounds(1-3)were isolated from the endophytic fungus A.fumigatus.Their structures were identified as methyl 4-(3,4-dihydroxyphenyl)-2-hydroxy-4-oxobutanoate(1),arctiin(2)and 3-hydroxy-4-methoxy-phenylethanol(3).Compound 1 is a new phenolic component named as methyl 4-(3,4-dihydroxyphenyl)-2-hydroxy-4-oxobutanoate(1).

关 键 词：霸王鞭 烟曲霉 酚类化合物 结构鉴定 大戟属 

分 类 号：Q949.753.5[生物学—植物学]