Friedel-Crafts trifluoromethylthiolation of electron-rich(hetero)arenes with trifluoromethylthio-saccharin in 2,2,2-trifluoroethanol(TFE)  

作　　者：Shiyao Lu Wenbo Chen Qilong Shen 

机构地区：[1]Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power,Shanghai University of Electric Power,Shanghai 200090,China [2]Key Laboratory of Organofluorine Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2019年第12期2279-2281,共3页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China (Nos.21625206, 21632009,21572258,21421002);the Natural Science Foundation of Shanghai (No.17ZR1447100);the Science and Technology Commission of Shanghai Municipality (No.14DZ2261000)

摘　　要：A promoter-free Friedel-Crafts trifluoromethylthiolation of electron-rich arenes and heteroarenes with N-trifluoromethylthiosaccharin 5 using 2,2,2-trifluoroethanol(TFE) as the solvent was described.The reactions were conducted at 40℃and a variety of common functional groups were compatible.A promoter-free Friedel-Crafts trifluoromethylthiolation of electron-rich arenes and heteroarenes with N-trifluoromethylthiosaccharin 5 using 2,2,2-trifluoroethanol(TFE) as the solvent was described.The reactions were conducted at 40℃and a variety of common functional groups were compatible.

关 键 词：Fluorine Trifluoromethylthio FRIEDEL-CRAFTS ARENE TRIFLUOROETHANOL 

分 类 号：TQ460.1[化学工程—制药化工]