血清尿激酶型纤溶酶原激活剂、环氧合酶2在口腔鳞状细胞癌中的表达及意义  

The expression and significance of serum urokinase-type plasminogen activator and cyclooxygenase 2 in oral squamous cell carcinoma

作　　者：肖艳波[1] 张琳[1] 李群 左巧娟[1] 王宗康 XIAO Yanbo;ZHANG Lin;LI Qun;ZUO Qiaojuan;WANG Zongkang(Department of Dental,The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410000,China)

机构地区：[1]湖南中医药大学第一附属医院口腔科

出　　处：《安徽医药》2020年第3期481-484,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨血清尿激酶型纤溶酶原激活剂(uPA)、环氧合酶2(COX⁃2)对口腔鳞状细胞癌(OSCC)病人病情发生发展的影响。方法选取2017年2—12月湖南中医药大学第一附属医院确诊的OSCC病人90例(OSCC组),健康体检志愿者90例作为对照组,检测两组研究对象的血清uPA、COX⁃2水平,按照不同病理学分级、不同临床分期、是否发生淋巴结转移OSCC病人中的血清uPA、COX⁃2水平差异。结果OSCC组病人血清uPA、COX⁃2水平[(5.44±2.71)mg/L、(27.8±9.3)IU/L]显著的高于对照组[(1.39±0.48)mg/L、(6.5±2.3)IU/L],均差异有统计学意义(t=13.960、21.092,P<0.05);临床分期(Ⅲ期+Ⅳ期)、发生淋巴结转移的OSCC组病人血清uPA水平[(7.06±2.26)mg/L、(6.49±2.28)mg/L]显著的高于临床分期(Ⅰ期+Ⅱ期)、未发生淋巴结转移的OSCC组病人[(4.20±2.56)mg/L、(4.67±2.55)mg/L],均差异有统计学意义(t=-5.365、3.525,P<0.05);在不同病理学分化的OSCC病人中,血清uPA水平差异无统计学意义(t=-0.831,P>0.05);临床分期(Ⅲ期+Ⅳ期)、发生淋巴结转移、低分化的OSCC组病人血清COX⁃2水平[(32.5±8.4)IU/L、(33.0±7.3)IU/L、(34.6±8.7)IU/L]显著的高于临床分期(Ⅰ期+Ⅱ期)、未发生淋巴结转移及高中分化的的OSCC组病人[(24.1±7.6)IU/L、(23.2±8.8)IU/L、(23.8±9.0)IU/L],均差异有统计学意义(t=-4.885、5.655、-5.756,P<0.05)。结论OSCC组病人血清uPA、COX⁃2水平较健康对象显著升高,可能对OSCC的侵袭转移起促进作用。Objective To investigate effect of serum urokinase⁃type plasminogen activator(uPA)and cyclooxygenase 2(COX⁃2)expression levels in the development of oral squamous cell carcinoma(OSCC)patients.Methods A total of 90 patients with OSCC diagnosed in The First Affiliated Hospital of Hunan University of Chinese Medicine from February 2017 to December 2017(OSCC group)and 90 healthy volunteers(control group)were selected.The serum levels of uPA and COX⁃2 were measured in the two groups.Differences in the serum uPA and COX⁃2 levels in the patients with OSCC who had pathological grades,different clinical stages,and whether or not lymph node metastasis occurred.Results The serum levels of uPA and COX⁃2 in the OSCC group[(5.44±2.71)mg/L,(27.8±9.3)IU/L]were significantly higher than those in the control group[(1.39±0.48)mg/L,(6.5±2.3)IU/L](The t values are:13.960,21.092,P<0.05).The clinical stage(stage III+IV)and the OSCC group with lymph node metastasis had significant higher serum uPA levels[(7.06±2.26)mg/L,(6.49±2.28)mg/L]than patients at clinical stage(stage I+II)and OSCC patients with no lymph node metastasis[(4.20±2.56)mg/L,(4.67±2.55mg/L).The difference was statistically significant(The t values are:-5.365,3.525,P<0.05).In different pathologically differentiated OSCC patients,serum uPA levels was with no statistical significance(t=-0.831,P>0.05).The serum COX⁃2 level of clinical stage(stage III+IV),lymph node metastasis,poorly differentiated OSCC group[(32.5±8.4)IU/L,(33.0±7.3)IU/L,(34.6±8.7)IU/L]was significantly higher than the clinical stage(stageⅠ+Ⅱ)and the patients with lymph node metastasis and high⁃differentiation OSCC[(24.1±7.6)IU/L,(23.2±8.8)IU/L,(23.8±9.0)IU/L].The difference was statistically significant(The t values are:-4.885,5.655,-5.756,P<0.05).Conclusions The serum levels of uPA and COX⁃2 in the OSCC group were significantly higher than those in healthy subjects,which may promote the invasion and metastasis of OSCC.

关 键 词：口腔肿瘤 肿瘤 鳞状细胞 尿激酶型纤溶酶原激活剂 环氧化酶2 淋巴转移 

分 类 号：R739.8[医药卫生—肿瘤]