图形视网膜电图在原发性开角型青光眼患者视网膜神经纤维层厚度测量中的应用及影响因素分析  

Application of pattern electroretinogram in measuring the thickness of retinal nerve fiber layer in patients with primary open-angle glaucoma and analysis of influencing factors

作　　者：熊云帆 李琴[1] XIONG Yunfan;LI Qing(Department of Ophthalmology,the First Affiliated Hospital of Kunming Medical University,Yunnan Province,Kunming 650000,China)

机构地区：[1]昆明医科大学第一附属医院眼科

出　　处：《中国医药导报》2020年第6期111-114,共4页China Medical Herald

基　　金：国家自然科学基金资助项目（81760170）

摘　　要：目的分析图形视网膜电图(PERG)在原发性开角型青光眼患者视网膜神经纤维层厚度测量中的应用及影响因素,为临床提供相应的理论指导。方法选取2018年7月~2019年6月昆明医科大学第一附属医院眼科收治的早期原发性开角型青光眼患者60例(120眼)作为观察组,另选取同期收治的60例正常人群作为对照组。采用PERG分别对视网膜神经纤维厚度进行检测,比较两组PERG的检测情况,进行单因素和多因素分析PERG检测的影响因素。结果观察组N95振幅和N95时间均低于对照组,差异均有统计学意义(均P <0.05)。两组年龄、病程、屈光度、眼压比较,差异均有统计学意义(均P<0.05);两组性别、眼科合并症、既往手术史资料比较,差异无统计学意义(P> 0.05)。性别、年龄、病程、屈光度等视为自变量,检测的准确性视为因变量,行logistic多因素回归分析显示,年龄和屈光度为影响因素(均P<0.05)。结论PERG测定开角型青光眼具有较高的敏感性,但容易受到年龄、屈光度等因素的影响,多种方式联合检测,可有效提升开角型青光眼的早期诊断率,值得临床推广。Objective To analyze the application and influencing factors of pattern electroretinogram(PERG) in measuring the thickness of retinal nerve fiber layer in patients with primary open-angle glaucoma,and to provide corresponding theoretical guidance for clinical practice.Methods A total of 60 patients(120 eyes) with early primary openangle glaucoma admitted to Department of Ophthalmology,First Affiliated Hospital of Kunming Medical University from July 2018 to June 2019 were selected as the observation group,and 60 normal people admitted during the same period were selected as the control group.The thickness of retinal nerve fibers was detected by PERG,respectively.The detection conditions of PERG in the two groups were compared,and the influencing factors of PERG detection were analyzed by single and multiple factors.Results The amplitude and time of N95 in the observation group were lower than those in the control group,and the differences were statistically significant(all P <0.05).Age,course of disease,diopter,intraocular pressure of the two groups were compared,and the differences were statistically significant(all P <0.05).There was no significant difference in gender,ophthalmic complications and previous surgical history(P> 0.05).Gender,age,course of disease and diopter were regarded as independent variables,while the accuracy of test was regarded as dependent variables.Logistic multivariate regression analysis showed that age and diopter were influencing factors(all P <0.05).Conclusion The determination of open-angle glaucoma by PERG is highly sensitive,but it is easily affected by age,diopter and other factors.Multiple methods of combined detection can effectively improve the early diagnosis rate of open-angle glaucoma,which is worthy of clinical promotion.

关 键 词：图形视网膜电图 视网膜神经纤维厚度 影响因素 

分 类 号：R77[医药卫生—眼科]