基于关联规则和因子分析挖掘中医外治恶性腹水用药配伍规律  

Data mining of external application of traditional Chinese medicine for malignant ascites based on medication rules and factor analysis

作　　者：王贵 于然[1,2] 娄彦妮 李园[2] 贾立群[2] WANG Gui;YU Ran;LOU Yanni;LI Yuan;JIA Liqun(Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Oncology of Integrative Chinese and Western Medicine,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中日友好医院中西医结合肿瘤科,北京100029

出　　处：《中国医药导报》2020年第6期157-160,164,共5页China Medical Herald

基　　金：北京市科技计划项目“十病十药”专项（Z161100001816015）

摘　　要：目的探讨中医外治恶性腹水的用药规律。方法以"恶性腹水""中医外治"为主题词,对中国知网、万方、维普自建库至2019年6月的数据库资源进行全面检索,纳入中医外治恶性腹水的方药,进行关联规则分析聚类及因子分析。结果共搜集符合纳入标准的方剂73首,其中使用频数≥10的高频药物共20味,其中桂枝(35次)、黄芪(32次)、甘遂(31次)、牵牛子(28次)、茯苓(25次)、莪术(22次)最为常用,以温性药、苦味药居多,多归于脾、肺经。关联规则分析发现支持度>16%的药对组合共8个,提升度>3的药对组合共17个,聚类分析可归为4大类,因子分析提取10个公因子。结论恶性腹水的外治用药以温阳益气、利水渗湿为主,配以活血化瘀药。Objective To explore the medication rules of external treatment of traditional Chinese medicine for malignant ascites.Methods Taking "malignant ascites" and " external treatment of traditional Chinese medicine" as the theme words,comprehensive search of the database of CNKI,Wanfang and VIP from its inception to June 2019 was conducted.The formulas of external treatment of traditional Chinese medicine for malignant ascites were included and the association rule,clustering and factor analysis were carried out.Results A total of 73 prescriptions meeting the inclusion criteria were collected,among which 20 high-frequency drugs with frequency≥10 were used,including Cinnamon(35 times),Astragalus(32 times),Kansui(31 times),Petunia(28 times),Poria(25 times),Curcuma(22 times) were the most commonly used,most of which were warm drugs and bitter drugs,mostly attributed to spleen and lung meridian.Association rule analysis found that there were 8 drug pair combinations with support> 16% and 17 drug pair combinations with promotion> 3.Cluster analysis can be classified into 4 categories,and factor analysis extracted 10 common factors.Conclusion The principle of external treatment of malignant ascites is mainly "warming yang and benefiting qi", "benefiting water infiltration and dampness",and "promoting blood circulation and removing blood stasis".

关 键 词：恶性腹水 中医外治 关联规则 用药规律 因子分析 

分 类 号：R572[医药卫生—消化系统]