基于肠-肾轴理论浅析膳食纤维对慢性肾病的影响  

Influence of dietary fiber on chronic kidney disease:Base on the gut-kidney axis theory

作　　者：谢小慧 代思源[1] 戴艳玲[1] 宁建平[1] XIE Xiaohui;DAI Siyuan;DAI Yanling;NING Jianping(Department of Nephrology,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院肾内科

出　　处：《中南大学学报（医学版）》2020年第2期193-197,共5页Journal of Central South University ：Medical Science

摘　　要：慢性肾病(chronic kidney disease,CKD)可引起肠道菌群失调及肠道屏障功能受损,而肠道稳态的破坏有利于肠源性毒素的产生及肠腔细菌、内毒素的易位,加重CKD的尿毒症毒性及全身性炎症。膳食纤维可靶向作用于"肠-肾轴",从而降低CKD的尿毒症毒素水平及减轻全身性炎症。膳食纤维有望成为治疗CKD的新策略。Chronic kidney disease(CKD) can result in alteration of intestinal flora and damage of intestinal barrier function. Intestinal dysbios is contributes to the generation of colon-derived uremic solutes and the translocation of bacteria and endotoxins from gut lumen into the bloodstream, subsequently increasing uremic toxicity and triggering systemic inflammation,which is related to CKD progression and many complications. Studies have revealed that dietary fiber can reduce uremic toxin levels and systemic inflammation in CKD through targeting the"gut-kidney axis". Dietary fiber seems to be a promising measure for CKD treatment.

关 键 词：肠-肾轴 慢性肾病 膳食纤维 尿毒症毒素 全身性炎症 

分 类 号：R692[医药卫生—泌尿科学]