组蛋白赖氨酸特异性去甲基化酶1A在肿瘤发生发展中的作用  

Function of histone demethylasehistone lysine-specific demethylase 1A in tumor initiation and progression

作　　者：张夕梅 安心丽 祝顺琴[1] 刘堰[1] Ximei Zhang;Xinli An;Shunqin Zhu;Yan Liu(School of Life Sciences,Southwest University,Chongqing 400716,China)

机构地区：[1]西南大学生命科学学院

出　　处：《生物工程学报》2020年第2期226-240,共15页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(No.31501100)资助~~

摘　　要：组蛋白赖氨酸特异性去甲基化酶1A (Histone lysine-specific demethylase 1A,KDM1A)作为组蛋白赖氨酸特异性去甲基化酶(Histonelysine-specificdemethylase)家族的一员,在信号传导、染色体重构、胚胎发育、造血和糖脂代谢等生物学过程中起着重要的作用。近年来的研究及临床证据表明,KDM1A的表达与肿瘤的发生发展密不可分,通过与不同的复合物结合并介导不同的下游信号通路,对多种肿瘤的生长增殖起着关键的调节作用,例如前列腺癌、乳腺癌、肺癌和肝癌等。在大多数情况下,KDM1A在肿瘤的发生发展中扮演着促癌基因角色。文中结合近年来有关文献,阐述了KDM1A在多种肿瘤发生及发展中的研究进展,总结了其作用机制,并对以KDM1A为靶点的抑癌治疗的应用前景进行了展望。As a member of the histone lysine-specific demethylase family, KDM1 A plays a pivotal role in biological processes including signal transduction, chromatin reprogramming, embryo development, hematopoiesis, glucose and lipid metabolism. Recently, increasing studies and clinical evidences suggest that the expression of KDM1 A is related to initiation and development of tumors and plays a key role in regulating of initiation and development of tumors, such as prostate cancer, breast cancer, lung cancer and liver cancer. KDM1 A binds to distinct complexes and mediates different downstream signaling pathways. However, KDM1 A often plays an oncogenic role in the initiation and development of tumors. Based on the current literatures, we describe the latest research of KDM1 A in the initiation and progression of various tumors, and summarize its mechanism of actions, to provide clues for cancer therapy.

关 键 词：组蛋白赖氨酸特异性去甲基化酶1A 肿瘤发生 肿瘤发展 组蛋白去甲基化酶 

分 类 号：R730.2[医药卫生—肿瘤]