急性脑梗死患者氯吡格雷抵抗的影响因素分析  

Influencing factors of clopidogrel resistance in patients with acute cerebral infarction

作　　者：穆素会 李文杰[1] 李静[1] Mu Suhui;Li Wenjie;Li Jing(The Third Division of Neurology Department,Zhengzhou Yihe Hospital Affiliated to Henan University,Zhengzhou 450000,Henan,China)

机构地区：[1]河南大学附属郑州颐和医院神经内科三病区

出　　处：《右江民族医学院学报》2020年第1期39-41,共3页Journal of Youjiang Medical University for Nationalities

摘　　要：目的探讨急性脑梗死患者氯吡格雷抵抗的发生率与影响因素。方法选取我院2016年11月-2018年12月110例急性脑梗死患者为研究对象,对其给予为期一周的氯吡格雷抗血小板聚集治疗,统计氯吡格雷抵抗发生率并分析其影响因素。将全部患者分为抵抗组(35例)和参照组(75例)进行比较分析。结果治疗一周后,氯吡格雷抵抗发生率为31.82%(35/110)。抵抗组患者低密度脂蛋白水平高于3.12mmol/L、2型糖尿病以及空腹血糖水平高于6.1mmol/L的人数比例均明显高于参照组(P <0.05)。Logistic回归分析结果显示,低密度脂蛋白水平高于3.12mmol/L以及2型糖尿病是引起急性脑梗死患者发生氯吡格雷抵抗的独立危险因素(P <0.05)。结论使用氯吡格雷治疗急性脑梗死易发生氯吡格雷抵抗,2型糖尿病、低密度脂蛋白高于3.12mmol/L是发生氯吡格雷抵抗的独立危险因素。Objective To study the incidence and influencing factors of clopidogrel resistance in patients with acute cerebral infarction. Methods A total of 110 patients with acute cerebral infarction in our hospital from November 2016 to December 2018 were selected as the study objects.All patients received anti-platelet aggregation treatment with clopidogrel for one week and the incidence of clopidogrel resistance was calculated and its influencing factors were analyzed.All patients were divided into a resistance group(n =35)and a reference group(n =75)for comparison and analysis. Results One week after treatment,the incidence of clopidogrel resistance was 31.82%(35/110).The clopidogrel resistance group had higher proportions of patients whose low density lipoprotein(LDL)was over 3.12 mmol/L,who suffered with type 2 diabetes mellitus and whose fasting blood glucose was over 6.1 mmol/L than the control group(P <0.05).Results of logistic regression analysis showed that LDL>3.12 mmol/L and type 2 diabetes mellitus were independent risk factors for clopidogrel resistance in patients with acute cerebral infarction(P <0.05). Conclusion Treating acute cerebral infarction with clopidogrel easily induces clopidogrel resistance.Type 2 diabetes mellitus and low density lipoprotein>3.12 mmol/L are independent risk factors for clopidogrel resistance.

关 键 词：糖尿病 2型 低密度脂蛋白 急性脑梗死 氯吡格雷抵抗 

分 类 号：R743.33[医药卫生—神经病学与精神病学]