慢波睡眠期持续性棘慢波的癫痫患者的临床及脑电图特征分析  

Characteristics of clinical manifestation and EEG in epilepsy with continuous spike-and-waves during slowwave sleep

作　　者：蒋萍[1] 马勋泰 孟桃 牟凌梅 Jing Piang;Ma Xuntai;Meng Tao;Mou Lingmei(Department of Neurology,the Second People’s Hospital of Yibin,Sichuan 644000,China)

机构地区：[1]宜宾市第二人民医院神经内科,四川644000 [2]成都医学院第一附属医院神经内科

出　　处：《脑与神经疾病杂志》2020年第3期159-162,共4页Journal of Brain and Nervous Diseases

基　　金：四川省医学科研课题计划(S18024）

摘　　要：目的探讨慢波睡眠期持续性棘慢波的癫痫(ECSWS)患儿的临床和脑电图(EEG)特征。方法总结13例ECSWS患儿的临床资料,并对患儿的临床表现、视频脑电图(VEEG)特征及治疗随访情况进行分析。结果本组13例患儿,平均年龄(6.4±1.7)岁。5例头颅MRI有结构性异常。13例患儿均有癫痫临床发作,癫痫发作类型多样,病后均出现神经心理和/或运动功能发育倒退。EEG具备特征性慢波睡眠期持续性棘慢波放电,棘慢波指数(SWI)超过85%。予以抗癫痫药物、部分患儿加用肾上腺皮质激素治疗6月后10例(77%)有效,随访3年,大部分患儿EEG及神经认知状况和运动功能改善。结论ECSWS系一种具有特征性EEG的癫痫综合征,早期诊断治疗可改善患儿神经心理和运动功能。Objective To identify characteristics of clinical and electroencephalogram(EEG) in epilepsy with continuous spike-and-waves during slow-wave sleep(ECSWS).Methods To review the characters of clinic,VEEG and the response to therapy of 13 patients with ECSWS.Results The 13 patients were average age of(6.4±1.7)years,MRI of brain was abnormal in 5 of 13 patients.All the 13 cases had clinical seizures.The re were different types of seizures.Neuropsychological and motor functional regression was found after the disease.There was phenomenon of CSWS in their EEG,The spike-slow wave index(SWI) was over 85%.Antiepileptic drugs and adrenal cortex hormone therapy were effective in 10 cases(77%) after 6 months.Follow-up of 3 years,VEEG,neurocognitive status and motor function were improved in most children.Conclusion ECSWS is a pattern of epileptic syndrome characterized by EEG,early diagnosis and treatment can improve the neuropsychological and motor function.

关 键 词：慢波睡眠期持续性棘慢波的癫痫 临床表现 脑电图 治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学]