胃癌患者围手术期循环肿瘤细胞变化及其与临床病理分期的相关性  

Correlation of perioperative circulating tumor cells with clinicopathologic features of gastric cancer patients

作　　者：葛海燕[1,2] 张振宇 茅丽玲 纪昉 朱哲 高玮[1] 付正伟[1] GE Hai-yan;ZHANG Zhen-yu;MAO Li-ling;JI Fang;ZHU Zhe;GAO Wei;FU Zheng-wei(Dept.of Gastrointestinal Surgery,East Hospital,Tongji University School of Medicine,Shanghai 200120,China;Second People's Hospital,Pinghu 314200,Zhejiang Province,China;Nanxiang Community Health Service Center,Jiading District,Shanghai 201802,China)

机构地区：[1]同济大学附属东方医院胃肠肛肠外科,上海200120 [2]浙江省平湖市第二人民医院,浙江平湖314200 [3]上海市嘉定区南翔镇社区卫生服务中心,上海201802

出　　处：《同济大学学报（医学版）》2020年第1期47-50,共4页Journal of Tongji University(Medical Science)

基　　金：上海市科学技术委员会项目(16411970800);浙江省嘉兴市科技局课题项目(2015AY23071)

摘　　要：目的了解胃癌患者围手术期外周血中循环肿瘤细胞(circulating tumor cells, CTCs)数量的变化及其与肿瘤病理分期的相关性。方法应用肿瘤细胞微流控芯片技术检测手术前1天、手术后1周胃癌患者CTCs,并与其临床病理资料进行对比,阐明两者之间的相关性。结果在92例胃癌患者中,术前外周血CTCs阳性者58例,阳性率为63%;CTCs阳性的胃癌患者与肿瘤浸润深度、脉管侵犯、神经侵犯都具有相关性(P=0.02);术后1周60.5%患者CTCs消失或减少,CTCs数量没有变化甚至增多者主要见于TNM分期晚(Ⅳ期)患者。结论胃癌患者外周血中CTCs与其临床病理分期具有密切相关性。Objective To investigate the correlation of perioperative circulating tumor cells(CTCs) with clinicopathologic features in gastric cancer patients. Methods The circulating tumor cells were detected with micro-fluid chip technique in 92 gastric cancer patients at 1 day before operation and 1 week after operation. The relationship between the CTCs and tumor clinicopathologic features of patients was analyzed. Results The positive CTCs were detected in 58 cases(63%) 1 day before operation. The positive CTCs were significantly correlated with cancer infiltration depth, blood vessel infiltration, and nerve infiltration(P=0.02). The CTCs was negative or decreased in 60.5% of patients after 1 week of operation. The CTCs were increased or not changed mainly in TNM stage Ⅳ patients. Conclusion The positive CTCs in gastric cancer patients are closely correlated with clinicopathologic features.

关 键 词：胃癌 循环肿瘤细胞 肿瘤病理分期 胃癌根治术 临床研究 

分 类 号：R730.49[医药卫生—肿瘤]