肺保护性通气策略对胸腔镜肺癌根治术患者术后炎症反应及氧化应激的影响  

Effect of lung protective ventilation strategy on inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer

作　　者：邹斌 汪剑冰 唐朗 郭昌莹[1] ZOU Bin;WANG Jian-bing;TANG Lang;GUO Chang-ying(The Second Department of Thoracic Surgery,Jiangxi Cancer Hospital,Nanchang,330029,China)

机构地区：[1]江西省肿瘤医院胸外二科,江西南昌330029

出　　处：《中国当代医药》2020年第5期102-104,共3页China Modern Medicine

摘　　要：目的研究肺保护性通气策略对胸腔镜肺癌根治术患者术后炎症反应及氧化应激的影响。方法选取2017年7月~2018年7月我院收治的75例胸腔镜肺癌根治术患者作为研究对象,按照随机数表法将其分为观察组(38例)和对照组(37例)。对照组患者采用常规通气策略,观察组患者采用肺保护性通气策略。比较两组患者手术前后的炎症反应指标[白介素-10(IL-10)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、氧化应激反应指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]。两组患者的肺功能以标准的肺功能量表进行评分,并记录两组患者术后3 d内肺部并发症的发生情况。结果两组患者术后的IL-10、IL-8、TNF-α水平均低于术前,差异有统计学意义(P<0.05);观察组患者术后的IL-10、IL-8、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。两组患者术后的MDA均低于术前,SOD、肺功能评分均高于术前,差异有统计学意义(P<0.05);观察组患者术后的MDA低于对照组,SOD、肺功能评分均高于对照组,差异有统计学意义(P<0.05)。观察组患者的并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论肺保护性通气策略对胸腔镜肺癌根治术患者术后炎症反应与氧化应激均有显著的降低作用,还能改善肺功能,在实际临床中有较高的应用价值,值得推广。Objective To study the effect of lung protective ventilation strategy on inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer.Methods A total of 75 patients with thoracoscopic radical resection of lung cancer admitted to our hospital from July 2017 to July 2018 were selected as the research objects.All patients were divided into observation group(38 cases)and control group(37 cases)according to the random number table method.The control group was treated with conventional ventilation strategy,and the observation group was treated with lung protective ventilation strategy.The inflammatory response indexes(interleukin-10[IL-10],interleukin-8[IL-8],tumor necrosis factor-α[TNF-α])and oxidative stress indexes(malondialdehyde[MDA],superoxide dismutase[SOD])were compared between the two groups before and after operation.The pulmonary function of the two groups was scored with the standard pulmonary function scale.The incidence of pulmonary complications was recorded within 3 days after operation in both groups.Results The levels of IL-10,IL-8 and TNF-αafter operation in the two groups were lower than those before operation,and the differences were statistically significant(P<0.05).The levels of IL-10,IL-8 and TNF-αin the observation group after operation were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of MDA in the two groups after operation were lower than those before operation,SOD and pulmonary function score were higher than those before operation,and the differences were statistically significant(P<0.05).The MDA of the observation group after operation was lower than that of the control group,SOD and pulmonary function score were higher than those of the control group,and the differences were statistically significant(P<0.05).The total incidence rate of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The lu

关 键 词：肺保护性通气策略 胸腔镜肺癌根治术 术后 炎症反应 氧化应激 

分 类 号：R735.1[医药卫生—肿瘤]