卵磷脂修饰改性聚乳酸微球的制备及表征  

Preparation and characterization of polylactic acid microspheres modified with lecithin

作　　者：丁忱 陈顺玉 肖秀峰 DING Chen;CHEN Shunyu;XIAO Xiufeng(College of Chemistry and Materials, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Normal University, Fuzhou 350007, China)

机构地区：[1]福建师范大学化学与材料学院福建省先进材料化工基础重点实验室

出　　处：《福建工程学院学报》2020年第1期12-17,共6页Journal of Fujian University of Technology

摘　　要：采用氨解结合乳化及热致相分离的技术来制备改性聚乳酸微球,通过浸泡法让卵磷脂包裹在改性微球上,进一步提高改性微球的亲水性。探讨了卵磷脂溶液的浓度、浸泡时间对改性微球形貌和亲水性能的影响。实验结果表明,卵磷脂修饰改性微球的最佳制备工艺条件为:卵磷脂溶液的浓度为1%,浸泡时间为5 h,在此条件下制备的微球卵磷脂包裹均匀且亲水性得到了改善。通过红外光谱,X射线光电子能谱表征微球,结果表明卵磷脂已经成功接枝到改性微球上,通过水接触角测试,卵磷脂修饰后的改性微球亲水性得到了进一步提高。The modified polylactic acid microspheres were prepared by ammonolysis combined with emulsification and thermally induced phase separation.The lecithin was wrapped on the modified microspheres by immersion so as to further improve the hydrophilicity of the modified microspheres.The effects of concentration and soaking time of lecithin solution on the morphology and the hydrophilicity of modified microspheres were investigated.Results show that the optimum preparation conditions for modified microspheres were as follows:the concentration of lecithin solution was 1%,and the soaking time was 5 hours.The microspheres prepared under these conditions were uniformly encapsulated and their hydrophilicity was improved.Infrared spectroscopy and X-ray photoelectron spectroscopy were used to characterize these microspheres,and results show that lecithin had been successfully grafted onto the modified microspheres;the hydrophilicity of modified microspheres modified by lecithin was further improved by water contact angle test.

关 键 词：改性微球 卵磷脂 亲水性 

分 类 号：O63[理学—高分子化学]