脑胶质母细胞瘤的治疗现状与展望  

Current status and prospect in the treatment of glioblastoma

作　　者：蒋海辉[1] 林松[1] Jiang Haihui;Lin Song(Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing Neurosurgical Institute,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经外科,北京市神经外科研究所,100070

出　　处：《中华外科杂志》2020年第1期70-74,共5页Chinese Journal of Surgery

基　　金：国家自然科学基金(81771309)。

摘　　要：脑胶质母细胞瘤(GBM)是最常见的颅内原发性恶性肿瘤。以外科手术切除为主的综合治疗模式是改善GBM预后、提高患者生存质量的关键,最大范围地安全切除是当前新诊断的GBM的手术原则。本文回顾过去20年GBM在手术、放疗、化疗、靶向治疗、免疫治疗领域的研究进展,重点探讨了新诊断GBM与复发GBM在治疗策略方面的异同点,分析了老年GBM患者的治疗、假性进展、假性有效等临床难点问题,并对未来GBM治疗的发展方向进行展望。Glioblastoma(GBM)is the most common primary intracranial malignancy.The comprehensive treatment mode based on surgical resection has become the key to improve the prognosis of GBM and the quality of life of patients.This article reviews the progress of GBM in the fields of surgery,radiotherapy,chemotherapy,targeted therapy and immunotherapy during the past twenty years,mainly explores the similarities and differences between the treatment strategies of newly diagnosed and recurrent GBM and analyzes the difficulties in the current clinical practice of GBM.

关 键 词：胶质母细胞瘤 治疗结果 精准医学 治疗 预后 

分 类 号：R73[医药卫生—肿瘤]