缺血性卒中患者认知功能障碍的危险因素分析  

Risk factors for cognitive impairment inpatients with ischemic stroke

作　　者：李先锋 周凤坤 吴李硕 吴育朗 韦金儒[1] Li Xianfeng;Zhou Fengkun;Wu Lishuo;Wu Yulang;Wei Jinru(Department of Neurology,the Fifth Affiliated Hospital of Guangxi Medical University,Nanning 53022,China)

机构地区：[1]广西医科大学第五附属医院神经内科二区

出　　处：《临床荟萃》2020年第1期37-40,共4页Clinical Focus

基　　金：南宁市科学研究与技术开发计划——南宁市脑卒中中心网络建设(20163142);广西壮族自治区卫生和计划生育委员会自筹经费科研课题——卒中后认知功能障碍早期筛查评估与干预的临床研究(Z20180671);南宁市青秀区科技计划项目——南宁市卒中后认知障碍筛查示范中心建设(2018028)

摘　　要：目的探讨急性缺血性卒中患者认知功能障碍的危险因素。方法纳入50例发生卒中后认知功能障碍(post-stroke cognitive impairment,PSCI)的缺血性卒中患者为病例组,以50例未发生PSCI的缺血性卒中患者作为对照组,比较两组患者的临床资料,并分析PSCI的相关因素。结果与对照组相比,病例组患者年龄更高,合并高血压、糖尿病的比例较高,LDL-C、UA、hs-CRP水平较高;颞叶梗死、丘脑梗死的比例较高(均P<0.05);两组教育程度及卒中次数相比差异有统计学意义(均P<0.05)。既往卒中2次及以上、糖尿病、LDL-C、hs-CRP水平升高、颞叶梗死是PSCI的危险因素;初中及以上文化程度是PSCI的保护因素。结论低文化程度、糖尿病、既往有卒中病史、LDL-C及hs-CRP水平升高、颞叶梗死的缺血性患者发生PSCI的风险更高。Objective To investigate the risk factors for cognitive impairment in patients with ischemic stroke.Methods Totally 50 ischemic stroke patients with poststroke cognitive impairment(PSCI)were enrolled as observation group,and another 50 ischemic stroke patients without PSCI were enrolled as control group.The clinical data of these two groups were compared,and the relevant factors of PSCI were analyzed.Results Compared with the control group,patients in observation group were older;the proportion of complication with hypertension and diabetes were higher;the levels of LDL-C,UA and hs-CRP were higher;the rate of thalamic infarction and temporal lobe infarction were higher(all P<0.05).There were statistically significant differences in education levels and stroke frequency between two groups(all P<0.05).The two or more times of previous stroke,diabetes,high levels of LDL-C and hs-CRP,and temporal lobe infarction were risk factors for PSCI;while middle school or above educational level was the protective factor for PSCI.Conclusion Ischemic stroke patients with low educational level,diabetes,previous history stroke,temporal lobe infarction,high levels of LDL-C and hs-CRP have higher risk for PSCI.

关 键 词：卒中 认知障碍 危险因素 

分 类 号：R743[医药卫生—神经病学与精神病学]