毛发中8种常见精神类药物的LC-MS/MS检测方法  

Determination of 8 psychotropic drugs in hair of personnel by LC-MS/MS

作　　者：侯峰[1] 杨崇俊[2] 张建强 刘冰洁 龙燕怡 HOU Feng;YANG Chongjun;ZHANG Jianqiang;LIU Bingjie;LONG Yanyi(Jining Psychiatric Hospital,Jining,272000;Criminal Science&Technology Tnstitute of Jining Public Security Bureau,Jining,272000;Jining Second People’s Hospital,Jining,272000;ABSciex Pte.Ltd,Shanghai,203350;Jining Medical University,Jining,272000)

机构地区：[1]济宁市精神病防治院,济宁272000 [2]山东省济宁市公安局刑事科学技术研究所,济宁272000 [3]济宁市第二人民医院,济宁272000 [4]上海爱博才思分析仪器贸易有限公司,上海203350 [5]济宁医学院,济宁272000

出　　处：《中国药物依赖性杂志》2019年第6期441-445,共5页Chinese Journal of Drug Dependence

摘　　要：目的:建立毛发中曲唑酮、利培酮、舍曲林、坦度螺酮、阿立哌唑、喹硫平、奥氮平、氯氮平的液相色谱串联质谱检测方法。方法:取毛发50 mg,洗净,放入含撞珠和甲醇水的研磨管,在研磨仪上研磨2 min,过滤后进行LC-MS/MS定性定量分析。结果:毛发中8种精神类药物在3 min内完成前处理,与常规的方法比较该方法回收率高、稳定性良好,检出限达0. 01 ng·mg-1,定量范围0. 01-10 ng·mg-1内线性关系均大于0. 99。结论:该方法操作简单、高效、灵敏、结果准确,适用于毛发中8种精神类药物定性定量分析。Objective:To establish the analytical method of trazodone,risperidone,sertraline,tandospirone,aripiprazole,quetiapine,olanzapine and clozapine in hair samples by LC-MS/MS.Methods:Take hair 50 mg,wash,put in a grinding tube containing beads and methanol,grind 2min on the grinding instrument,All analytes wereextracted by appropriate solvent and determined by LC-MS/MS.Results:For all analytes,Compared with conventional methods,this method has high recovery and good stability,LODs were 0.01 ng·mg-1,linear curve covered the range 0.01-10 ng·mg-1.Conclusion:This method was very simple,rapid and accurate,which can be used for determination of 8 psychiatric drugs in hair.

关 键 词：法医毒物分析 液相色谱质谱联用仪 精神类药物 毛发 高速研磨仪 

分 类 号：R749[医药卫生—神经病学与精神病学]