急性心源性脑栓塞患者血管再通术中应用替罗非班动脉灌注的疗效评估  

Evaluation of therapeutic effect of Tirofiban artery perfusion during vascular recanalization in patients with acute cardiogenic cerebral embolism

作　　者：李昀峰 彭俊霖 周木兰 Li Yunfeng;Peng Junlin;Zhou Mulan(The People's hospital of Gaozhou Gity,Gaozhou,Guangdong 525200)

机构地区：[1]高州市人民医院

出　　处：《基层医学论坛》2020年第5期604-606,共3页The Medical Forum

基　　金：茂名市科技计划项目（190311201705053）

摘　　要：目的 探讨急性心源性脑栓塞患者血管再通术中应用替罗非班动脉灌注的疗效。方法 纳入2017年3月—2019年3月入院接受治疗的急性心源性脑栓塞患者140例,随机分为对照组和研究组。对照组患者接受血管再通术尿激酶动脉灌注治疗,研究组在此基础上加用替罗非班,对比2组患者的NIHSS评分、CHADS2评分、HAS-BLED评分。结果 治疗前,2组患者NIHSS评分、CHADS2评分、HAS-BLED评分无统计学差异(P>0.05);治疗后,研究组NIHSS评分、CHADS2评分、HAS-BLED评分均低于对照组,差异具有统计学意义(P<0.05)。结论 急性心源性脑栓塞患者血管再通术中应用替罗非班动脉灌注治疗,能有效改善神经功能缺损,降低发生脑卒中以及出血的风险,值得在临床上进行推广。Objective To evaluate the therapeutic effect of tirofiban artery perfusion during vascular recanalization in patients with acute cardiogenic cerebral embolism.Methods In this study,140 patients with acute cardiogenic cerebral embolism admitted to hospital for treatment from March 2017 to March 2019 were included.The selected number of cases met the statistical requirements and were randomly divided into control group and research group.The control group received arterial perfusion therapy during vascular recanalization,and the research group received tirofiban arterial perfusion therapy during vascular recanalization.Under different treatment methods,the NIHSS score,CHADS2 score and HAS-BLED score of the two groups were compared.Results Before treatment,there was no difference in NIHSS score,CHADS2 score and HAS-BLED score between the two groups(P&gt;0.05).After treatment,NIHSS score,CHADS2 score and HAS-BLED score in the study group were lower than those in the control group,with statistical significance(p&lt;0.05).Conclusion The application of tirofiban artery perfusion therapy during vascular recanalization in patients with acute cardiogenic cerebral embolism can effectively improve the neurological deficits of patients and reduce the risk of stroke and hemorrhage.The research results confirm that it is worthy of clinical promotion.

关 键 词：急性心源性脑栓塞 血管再通术 替罗非班 动脉灌注 临床疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]