四味土木香散挥发油的β-环糊精包合工艺  

β-Cyclodextrin inclusion process for volatile oils of Siwei Tumuxiang Powder

作　　者：李娜 刘德旺 赵红梅 杭凌宇 张屏 包保全 LI Na;LIU De-wang;ZHAO Hong-mei;HANG Ling-yu;ZHANG Ping;BAO Bao-quan(College of Pharmacy,Inner Mongolia Medical University,Hohhot 010110,China)

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010110

出　　处：《中成药》2020年第3期558-563,共6页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金地区项目 (81460651);中国国家留学基金资助 (201808155053)。

摘　　要：目的建立四味土木香散挥发油的β-环糊精包合工艺。方法饱和水溶液法制备包合物。以β-环糊精与挥发油比例、包合温度、搅拌时间为影响因素,包合率、收率、包封率为评价指标,正交实验优化包合工艺。TLC、差示扫描量热(DSC)、傅里叶变换红外光谱(FTIR)、扫描电镜(SEM)进行表征。考察包合物在强光[(4 500±500)lx]、高湿(RH 90%,25℃)、高温(60℃)条件下的稳定性。结果最佳条件为β-环糊精与挥发油比例4∶1,包合温度50℃,搅拌时间2 h,包合率、收率、包封率分别为74.12%、83.12%、78.16%。挥发油包入β-环糊精空腔中,表明包合物制备成功。包合物在上述条件下的稳定性良好。结论该方法稳定可行,可用于包合四味土木香散挥发油。AIM To establish the β-cyclodextrin inclusion process for volatile oils of Siwei Tumuxiang Powder.METHODS Saturated aqueous solution method was adopted in the preparation of inclusion compounds. With(β-cyclodextrin)-volatile oil ratio, inclusion temperature and stirring time as influencing factors, inclusion rate, yield and encapsulation efficiency as evaluation indices, the inclusion process was optimized by orthogonal test. Characterization was performed by TLC, differential scanning calorimetry(DSC), Fourier transform infrared spectroscopy(FTIR) and scanning electron microscope(SEM). The stability of inclusion compounds was investigated under the conditions of strong light[(4 500±500) lx], high humidity(RH 90%, 25 ℃) and high temperature(60 ℃).RESULTS The optimal conditions were determined to be 4∶1 for(β-cyclodextrin)-volatile oil ratio, 50 ℃ for inclusion temperature, and 2 h for stirring time, the inclusion rate, yield and encapsulation efficiency were 74.12%, 83.12% and 78.16%, respectively. The inclusion of volatile oils into β-cyclodextrin indicated that inclusion compounds were successfully prepared. The inclusion compounds demonstrated good stability under the aforementioned conditions.CONCLUSION This stable and feasible method can be used for the inclusion of volatile oils of Siwei Tumuxiang Powder.

关 键 词：四味土木香散 挥发油 Β-环糊精 包合 饱和水溶液法 

分 类 号：R944[医药卫生—药剂学]