他汀类药物在脑卒中后癫痫中的治疗应用  

Recent advance in statins in post-stroke epilepsy

作　　者：李艳 狄政莉[2] 朱旭蓉[2] Li Yan;Di Zhengli;Zhu Xurong(School of Medicine,Yan'an University,Yan'an 71600,China;Department of Neurology,Xi'an Central Hospital,Xi'an 71000,China)

机构地区：[1]延安大学医学院,延安716000 [2]西安市中心医院神经内科,710000

出　　处：《中华神经医学杂志》2020年第2期211-213,共3页Chinese Journal of Neuromedicine

摘　　要：脑卒中后癫痫(PSE)作为卒中后常见并发症之一,严重影响患者生存质量。近年来越来越多的研究发现他汀类药物可以通过保护血脑屏障(BBB)的完整性、减轻神经递质的兴奋性毒性损害、减少神经细胞凋亡以及减少神经炎症等机制起到脑保护作用,从而降低PSE的发生风险。本文现围绕PSE的治疗以及他汀类药物在PSE中的应用综述如下。Post-stroke epilepsy(PSE),as one of the common complications after stroke,often seriously affect the quality of life of the survivors.In recent years,more and more studies have found that statins can protect the integrity of blood-brain barrier,alleviate excitotoxic damage of neurotransmitters,reduce neuronal apoptosis,and reduce neuroinflammation,which play a role in brain protection,thereby reducing the risk of PSE.This article reviews the treatment of PSE and application of statins in PSE.

关 键 词：脑卒中 癫痫 他汀类药物 

分 类 号：R74[医药卫生—神经病学与精神病学]