肝内胆管癌患者术后门静脉泵化疗的效果  

Efficacy of intrahepatic cholangiocarcinoma treated with chemotherapy through portal vein pump after radical surgery

作　　者：陶连元 董亚东[1] 余海波[1] 代坤甫 马家豪 贾刚 仓顺东[2] 蔡建平[1] 肖二卫 李德宇[1] Tao Lianyuan;Dong Yadong;Yu Haibo;Da Kunfu;Ma Jianhao;Jia Gang;Cang Shundong;Cai Jianping;Xiao Erwei;Li Deyu(Department of Hepatobiliary and Pancreatic Surgery,Henan Prorince Peoples Hospital,Zhengzhou 450003,China;Department of Medical Oncology,Henan Province People's Hospital,Zhengzhou,450003 China)

机构地区：[1]河南省人民医院肝胆胰腺外科,郑州450003 [2]河南省人民医院肿瘤内科,郑州450003

出　　处：《中华肝胆外科杂志》2020年第2期124-127,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：河南省重点研发与推广专项(科技攻关)(192102310119);吴阶平医学基金(LDWJPMF-104-2017005);河南省科技厅重点科技攻关项目(132102310096);河南省人民医院博士启动基金(ZC20180077);河南省卫生厅医学科技攻关计划项目(201403177)。

摘　　要：目的探讨肝内胆管癌(ICC)患者根治性手术后置入门静脉泵进行化疗的临床应用价值。方法回顾性分析河南省人民医院2012年6月至2016年6月行根治性手术的97例ICC患者临床资料。结果97例患者中经门静脉泵化疗14例(门静脉泵组),经外周静脉化疗33例(外周静脉组),术后未接受化疗患者50例(对照组)。三组患者性别和年龄差异均无统计学意义(均P>0.05)。生存分析结果显示门静脉泵组和外周静脉组患者的无病生存期(DFS)和总生存时间(OS)均明显好于对照组(均P<0.05)。虽然两化疗组差异无统计学意义(P>0.05),但门静脉泵组对于肝内转移灶的控制优于经外周静脉的全身化疗,其各项化疗副反应几乎都低于经外周静脉组。结论门静脉置入泵化疗可改善ICC患者手术预后,尤其是对肝内转移灶的控制效果较好,并且可减少全身化疗副反应。Objective To evaluate the clinical application value of portal vein implantation pump for chemotherapy in patients with intrahepatic cholangiocarcinoma(ICC)after radical surgery.Methods The clinical data of 97 patients with ICC who underwent radical surgery in Henan Peoples Hospital from June 2012 to June 2016 were retrospectively analyzed.Results Among the 97 patients,14 patients received portal venous pump chemotherapy(portal group),33 patients received peripheral venous chemotherapy(peripheral group),and 50 patients did not receive postoperative chemotherapy(control group).There were no statistically significant differences in gender and age between the three groups.The results of survival analysis indicated that the disease-free survival(DFS)period and overall survival(OS)time in the portal group and the peripheral group were significantly better than that in control group(both P<0.05).In addi-tion,despite the lack of statistical significance(P>0.05),for the control of intrahepatic metastasis,portal vein pump chemotherapy was better than that of systemie chemotherapy via peripheral vein,and almost all side effects of chemotherapy in the portal group were lower than those in the peripheral group.Conclusion Portal vein pump chemotherapy can improve the prognosis of intrahepatic bile duct patients,especially for the control of intrahepatic metastasis,and can reduce systemic side effects of chemotherapy.

关 键 词：胆管肿瘤 肝内胆管癌 门静脉置入泵 预后 化疗 

分 类 号：R735[医药卫生—肿瘤]