类淋巴系统与中枢神经系统病变的相关性研究进展  

Research Progress on Glymphatic System in Central Nervous System Disease

作　　者：卢鹤扬 冯一苇 崔梅 LU He-yang;FENG Yi-wei;CUI Mei(Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院神经内科,上海200040

出　　处：《中国临床神经科学》2020年第1期78-84,92,共8页Chinese Journal of Clinical Neurosciences

摘　　要：2012年在小鼠中首次发现了中枢神经系统存在类淋巴系统,并在动物实验和人体试验中得到进一步证实。类淋巴系统是依赖于水通道蛋白4的液体运输系统,分布于全脑,具有清除功能,其功能会受动脉搏动、睡眠等因素影响。近年来,越来越多的研究对类淋巴系统在中枢神经系统疾病中的作用进行了探索。文内介绍类淋巴系统的结构、功能和相关影响因素,回顾类淋巴系统在阿尔茨海默病、创伤性脑损伤、脑卒中、帕金森病等中枢神经系统疾病的相关研究进展,并对类淋巴系统在基础研究中有待解决的问题以及在临床诊断和治疗的应用进行综述。In 2012,a glymphatic system was identified in mice for the first time and has been confirmed in animal and human studies.The glymphatic system is a brain-wide and AQP4-dependent fluid transport system that serves the clearance function.Its functions can be influenced by several factors,such as pulsatility and sleep.In recent years,the glymphatic system has been explored by more and more researchers about its role on neurological diseases.The anatomical structure and functions of the glymphatic system as well as factors known to influence it were introduced,and the studies on its association with neurological diseases,including Alzheimer’s disease,traumatic brain injury,stroke and Parkinson’s disease were summarized.Meanwhile,the future study direction of basic medical science and clinical applications on diagnosis and treatment were discussed.

关 键 词：类淋巴系统 水通道蛋白4 睡眠 阿尔茨海默病 创伤性脑损伤 脑卒中 帕金森病 

分 类 号：R741[医药卫生—神经病学与精神病学]