骨桥蛋白与基质金属蛋白酶2在卵巢癌中的研究进展  

Research Progress in Osteopontin and Matrix Metalloproteinase-2 in Ovarian Cancer

作　　者：田心宇 尤琪(审校)[1] 龚承凤 程丛丛 李云秀 武金玉[1] 袁海涛 TIAN Xin-yu;YOU Qi;GONG Cheng-feng;CHENG Cong-cong;LI Yun-xiu;WU Jin-yu;YUAN Hai-tao(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Harbin Medical University,Harbin 151001,China)

机构地区：[1]哈尔滨医科大学附属第一医院妇产科,150001

出　　处：《国际生殖健康／计划生育杂志》2020年第2期172-176,共5页Journal of International Reproductive Health/Family Planning

摘　　要：卵巢癌是常见的妇科恶性肿瘤之一,其死亡率在妇科三大恶性肿瘤中居首位。具有起病隐匿、发展迅速及化疗耐药等特点,多数患者预后不良。骨桥蛋白(osteopontin,OPN)及基质金属蛋白酶2(matrix metalloproteinase 2,MMP-2)是新型肿瘤标志物,近年发现OPN和MMP-2在卵巢癌组织中高表达。OPN是一种分泌型磷酸化糖蛋白,可通过核因子κB(NF-κB)等途径抑制卵巢癌细胞凋亡,激活丝裂原活化蛋白激酶(MAPK)信号转导途径及改变细胞骨架,并且可通过激活磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)途径诱导卵巢癌细胞生长和增殖,促进细胞黏附及转移。MMP-2是一种Ⅳ型胶原酶,主要通过降解细胞外基质蛋白并参与细胞信号转导,与卵巢癌发生、发展、侵袭和转移密切相关。另外,OPN可通过多种信号途径激活MMP-2表达,加快卵巢癌细胞周围细胞外基质降解,二者联合检测能够提高卵巢癌诊断的敏感度和特异度,且对于评估卵巢癌的治疗预后方面也有应用价值。本文综述OPN与MMP-2在卵巢癌的转移、侵袭等生物学行为中的作用及其分子机制。Ovarian cancer is one of the common gynecological malignancies, and the mortality rate is the tope of three major gynecological malignancies. The hidden onset, rapid development and resistance to chemotherapy are of three characteristics, and most patients have a poor prognosis. Osteopontin(OPN) and matrix metalloproteinase 2(MMP-2) are two kinds of novel tumor markers. In recent years, the high expressions of OPN and MMP-2 in ovarian cancer were found. OPN is a secreted phosphorylated glycoprotein, which can inhibit ovarian cancer cell apoptosis through NF-κB and other pathways, and activate the MAPK signal transduction pathway and change the cytoskeleton. OPN can induce ovarian cancer cell growth and proliferation, and promote cell adhesion and metastasis, by activating the PI3 K/Akt pathway. MMP-2 is a type Ⅳ collagenase, which is mainly related to the occurrence, development, invasion and metastasis of ovarian cancer by degrading extracellular matrix proteins and participating in cell signal transduction. In addition, OPN can activate the MMP-2 expression through a variety of signal pathways, and accelerate the degradation of the extracellular matrix around ovarian cancer cells. The combined detection of the two markers can improve the sensitivity and specificity of ovarian cancer diagnosis. The combined detection is also helpful to predict the treatment prognosis. In this article,the effects of OPN and MMP-2 on the biological behaviors of ovarian cancer such as invasion and metastasis, and the molecular mechanism, were discussed.

关 键 词：骨桥蛋白质 基质金属蛋白酶2 卵巢肿瘤 生物标记 肿瘤 衔接蛋白质类 信号转导 

分 类 号：R737.31[医药卫生—肿瘤]