B细胞骨免疫在牙周炎中的作用  

The role of B cell osteoimmunity in periodontitis Shengjing Hospital, China Medical University, Shenyang

作　　者：林晓萍[1] 韩亚琨[1] LIN Xiaoping;HAN Yakun(Department of Stomatology,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院口腔科

出　　处：《口腔疾病防治》2020年第4期205-213,共9页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金(81570988)

摘　　要：牙槽骨吸收是牙周炎最为重要的病理特征,也是导致牙齿松动脱落、口腔功能异常的最主要原因。最新研究表明,宿主免疫是牙周炎过程中导致牙槽骨吸收的最主要因素。这一过程中所涉及的抗体、免疫细胞及炎症因子可引发局部成骨-破骨平衡紊乱,造成骨破坏。这种骨系统与免疫系统间的密切交互作用称为骨免疫。鉴于牙周炎宿主的主要免疫类型为适应性体液免疫,B细胞骨免疫在牙周炎发生发展过程中就显得尤为重要。因此,探索、揭示B细胞骨免疫,就成为深度解析牙周炎发生、发展与转归的有效途径。已有研究证实B细胞的发育过程伴随着骨密度或形态的改变,笔者回顾B细胞骨免疫在牙周炎病理进程中的作用相关研究表明,B细胞通过转录因子(如RANKL、PU.1、E2A等)调控骨细胞系的发育过程,此外,由B细胞所表达的多种细胞因子(如IFN-γ、IL-17、IL-10、TGF-β等)亦可参与骨系统细胞的调节。As the most important pathological feature of periodontitis, alveolar bone resorption also results in tooth loss and oral dysfunction. According to recent research, the host immune response is the major factor leading to alveolar bone resorption. Antibodies, immune cells and inflammatory cytokines involved in this procedure cause an imbalance of bone formation and destruction, which is called osteoimmunity. Given the importance of adaptive humoral immunity during periodontitis, B cells are considered crucial in the development of periodontitis. Therefore, establishing B cell osteoimmunity is an effective way for us to deeply assess the start, development and prognosis of periodontitis. It has been proven that the development process of B cells is accompanied by changes in bone density or morphology. We have reviewed previous literature to understand the role of B cell bone immunity in the pathological process of periodontitis,and the results showed that B cells regulate the development of bone cell lines through transcription factors(such as RANKL, PU.1, E2 A, etc.). In addition, various cytokines expressed by B cells(such as IFN-γ, IL-17, IL-10, TGF-β,etc.) can participate in the regulation of bone cells.

关 键 词：牙周炎 B细胞 骨免疫 细胞因子 骨吸收 转录因子 核因子κ-B配体受体激活剂 Γ-干扰素 白细胞介素-17 白细胞介素-10 

分 类 号：R781.4[医药卫生—口腔医学]