宫颈癌神经侵袭相关因素及预后分析  

Analysis of factors related to perineural invasion in cervical cancer and its relationship with prognosis

作　　者：杨楚琪 郑丽鸿 周莲娥[1] 万安霞[1] 王世军[1] Yang Chuqi;Zheng Lihong;Zhou Lian’e;Wan Anxia;Wang Shijun(Department of Gynecology and Obstetrics,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院妇产科,北京100053

出　　处：《中国医师杂志》2020年第2期184-187,共4页Journal of Chinese Physician

摘　　要：目的探讨神经侵袭(PNI)与宫颈癌临床病理特征的关系及其对预后的影响。方法回顾性分析2015年11月至2019年12月于首都医科大学宣武医院行广泛子宫切除术+盆腔淋巴结清扫术±腹主动脉旁淋巴结清扫术治疗的76例早期宫颈癌患者的临床病理特征及随访结果,探讨PNI的相关因素及对预后的影响。结果单因素分析提示PNI与肿瘤直径、间质浸润深度、脉管癌栓、淋巴结转移、临床分期有关(P <0. 05);多因素分析提示间质浸润深度是PNI的高危因素(P <0. 05)。K-M分析提示PNI阳性患者与阴性患者的无瘤生存时间、总生存时间差异无统计学意义(P> 0. 05)。结论PNI与间质浸润深度相关,PNI对于宫颈癌患者术后短期复发率及生存率无显著影响。Objective To investigate the relationship between perineural invasion(PNI)and the clinicopathological features of cervical cancer,and to explore its inHuence on the prognosis of cervical cancer patients.Methods Retrospective analysis the clinical data of 76 patients with early cervical cancer who received radical hysterectomy+pelvic lymphadenectomy±paraaortic lymphadenectomy from November 2015 to December 2019 in Xuanwu Hospital.The clinicopathological characteristics of the postoperative pathological results of cervical cancer patients were analyzed to explore lhe related factors of PNI and its influence on prognosis.Results Single factor analysis suggested that the inc idence of PNI was related to tumor diameter,depth of stroma invasion,lymph-vascular space invasion,lymph node metastasis and clinical stage(P<0.05).Multivariate analysis suggested that the infiltration depth of stroma invasion was the risk factor of PNI(P<0.05).K-M analysis showed that there was no significant difference in disease-free survival and overall survival between PNI positive and PNl negative patients(P>0.05).Conclusions PNI is related to the depth of interstitial infiltration.PNI has no significant effect on the short-temi recurrence rate and short-term survival rate of cervical cancer patients.

关 键 词：宫颈肿瘤 神经侵袭 预后 因素分析 统计学 

分 类 号：R737.33[医药卫生—肿瘤]