LncRNA-OVAAL的表达与子宫内膜浆液性乳头状癌患者术后复发和预后的关系  

The correlation between the expression of LncRNA-OVAAL and the recurrence and prognosis of u-terine papillary serous carcinoma after operation

作　　者：黄伟[1] 苗昊 彭林 Huang Wei;Miao Hao;Peng Lin(Department of Gynecologic Oncology,Hubei Cancer Hospital,Wuhan 430079,China;Department of Gynecology,Jilin Central Hospital,Jilin 132001,China)

机构地区：[1]湖北省肿瘤医院妇科肿瘤科,武汉430079 [2]吉林市中心医院妇科,132001

出　　处：《中国医师杂志》2020年第2期216-219,共4页Journal of Chinese Physician

基　　金：湖北省教育厅科研项目(B2017294)。

摘　　要：目的探讨长链非编码卵巢腺癌扩增RNA(LncRNA-OVAAL)与子宫内膜浆液性乳头状癌(UPSC)患者肿瘤复发和预后的关系。方法选取2012年12月至2013年12月于湖北省肿瘤医院收治的UPSC患者32例为观察组,其他良性疾病切除子宫患者30例为对照组,Real-time PCR检测入组患者血清中LncRNA-OVAAL表达情况,ROC曲线分析LncRNA-OVAAL在UPSC患者血清中的截断值;分析LncRNA-OVAAL表达与临床病理特征的关系;计算UPSC患者累计生存率并进行生存分析,Cox风险回归模型进行UPSC患者预后和总生存率的单因素和多因素分析。结果 LncRNAOVAAL在UPSC患者血清表达升高,与患者年龄、血管侵犯情况、绝经情况、复发情况及术前血清人附睾分泌蛋白4(HE4)、糖类抗原125(CA125)有关(P <0. 05);并且LncRNA-OVAAL高表达是UPSC患者术后复发和总体生存率的危险因素(P <0. 05)。结论 LncRNA-OVAAL高表达对预测UPSC患者术后复发及预后具有一定的评估价值。Objective To investigate the relationship between long non-coding ovarian adenocarcinoma amplified RNA(LncRNA-OVAAL)and tumor recurrence and prognosis in uterine papillary serous carcinoma(UPSC).Methods From May 2012 to November 2016,32 patients with UPSC in our hospital were selected as observation group,and 30 patients with other benign diseases were selected as control group.Real-time polymerase chain reaction(PCR)was used to detect the expression of LncRNA-OVAAL in the enrolled patients.The receiver operating characteristic(ROC)curve was used to analyze the cutoff value of LncRNA-OVAAL.The relationship between LncRNA-OVAAL expression and clinicopathological features was analyzed.The cumulative survival rate was calculated and survival analysis was performed.The Cox risk regression model was used to analyze the single-factor and multi-factor analysis of prognosis and o-verall survival rate.Results The expression of LncRNA-OVAAL in patients with UPSC was elevated,which was related to age,vascular invasion,menopause,recurrence and preoperative serum human epididymis protein 4(HE4)and carbohydrate antigen 125(CA125)(P<0.05).High expression of LncRNA-OVAAL was a risk factor for postoperative recurrence and overall survival in patients with UPSC(P<0.05).Conclusions The high expression of LncRNA-OVAAL has a certain evaluation value for predicting postoperative recurrence and prognosis in patients with UPSC.

关 键 词：RNA 长链非编码 子宫内膜浆液性乳头状癌 肿瘤复发 预后 

分 类 号：R737.33[医药卫生—肿瘤]