血清C肽检测在成人隐匿性自身免疫性糖尿病伴NAFLD患者中的临床意义  

Clinical significance of serum C-peptide in adult patients with latent autoimmune diabetes mellitus and nonalcoholic fatty liver disease

作　　者：曲真真[1] 陈羽[2] 崔玉 赵青[1] Qu Zhenzhen;Chen Yu;Cui Yuliang;Zhao Qing(Department of Endocrinology,Dezhou People’s Hospital,Dezhou 253000,China;Intensive Care Unit,Dezhou People’s Hospital,Dezhou 253000,China)

机构地区：[1]德州市人民医院内分泌科,253000 [2]德州市人民医院重症监护室,253000

出　　处：《国际医药卫生导报》2020年第4期484-487,491,共5页International Medicine and Health Guidance News

摘　　要：目的研究血清C肽检测在成人隐匿性自身免疫性糖尿病(LADA)伴非酒精性脂肪性肝病(NAFLD)患者中的临床意义。方法选取2017年1月至2019年3月本院收治的126例LADA患者为研究对象,开展回顾性分析。统计患者一般资料,分析LADA患者NAFLD发生情况,并采用多因素logistic回归分析法分析LADA患者并发NAFLD的独立影响因素,判断血清C肽对LADA伴NAFLD的预测价值。结果126例LADA患者中,有72例未发生NAFLD,占57.14%(72/126);54例LADA患者发生NAFLD,占42.86%(54/126);LADA患者并发NAFLD与体质量指数、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、胰岛素抵抗指数、空腹C肽、餐后2 h C肽有明显相关性,差异均有统计学意义(均P<0.05);除总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、胰岛素抵抗指数外,空腹C肽亦是LADA患者并发NAFLD的独立影响因素,差异有统计学意义(P<0.05)。结论血清C肽在预测LADA并发NAFLD中具有重要临床意义,高空腹C肽是LADA合并NAFLD的危险因素。Objective To study the clinical significance of serum C-peptide in adult patients with latent autoimmune diabetes(LADA)and nonalcoholic fatty liver disease(NAFLD).Methods 126 patients with LADA admitted to our hospital from January,2017 to March,2019 were included in the study,and were retrospective analyzed.The incidence of NAFLD in the patients was analyzed.The independent influencing factors of NAFLD in the patients were analyzed by multivariate logistic regression analysis;and the predictive value of serum C-peptide for the LADA patients with NAFLD was judged.Results Of the 126 LADA patients,57.14%(72/126)did not develop NAFLD,while 42.86%(54/126)did.BMI,total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,insulin resistance index,fasting C-peptide,and C-peptide 2 h after meal correlated with the occurrence of NAFLD in the LADA patients(all P<0.05).Besides total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,and insulin resistance index,fasting C-peptide was an independent influencing factors of the LADA patients complicated with NAFLD(P<0.05).Conclusion Serum C-peptide has important clinical significance in predicting LADA complicated with NAFLD.High fasting C-peptide is a risk factor for LADA complicated with NAFLD.

关 键 词：血清C肽 成人隐匿性自身免疫性糖尿病 非酒精性脂肪性肝病 

分 类 号：R575[医药卫生—消化系统] R587[医药卫生—内科学]