骨化醇类化合物的质谱裂解规律  

Mass Fragmentation Patterns of Calcified Alcohols

作　　者：蔡鹏俊[1] 陆静[1] 李悦[1] 陈泽 倪睿[2] CAI Pengjun;LU Jing;LI Yue;CHEN Ze;NI Rui(State Key Lab.of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 201203;National Pharmaceutical Engineering Research Center,Shanghai 201203)

机构地区：[1]中国医药工业研究总院上海医药工业研究院,创新药物与制药工艺国家重点实验室,上海201203 [2]药物制剂国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2020年第2期249-258,共10页Chinese Journal of Pharmaceuticals

摘　　要：以10个骨化醇类化合物为研究对象,采用电喷雾串联质谱及高分辨质谱元素组成进行分析,探讨该类化合物的质谱裂解规律。C-17位侧链基团的裂解差异、各环上断裂的位点以及结构中双键位置对质谱裂解的影响反映了该类化合物的结构特征。该研究可用于骨化醇类化合物的结构鉴定,为该类药物未知杂质的快速定性提供参考。Ten calcified alcohols were taken as the subjects, and their mass fragmentation patterns were explored based on the results of ESI-MS/MS and high resolution mass spectrometry. The structure characteristics of these analogues could be reflected from the fragmentations, such as the difference of C-17 chains, breaking point of rings, and the position of the double bond. This research could be used to identify calcified alcohols and provide some references for rapid qualitative analysis of unknown impurities.

关 键 词：骨化醇类化合物 电喷雾电离 二级质谱 高分辨质谱 裂解规律 

分 类 号：O657.72[理学—分析化学]