应用牙周再生技术预防下颌阻生第三磨牙拔除后邻牙远中牙周缺损疗效的Meta分析  

Effect of different periodontal regenerative techniques in preventing periodontal defects distal to mandibular second molars after extraction of impacted third molars:a systematic review and meta-analysis

作　　者：张宇[1] 薛洋[1] 李元[1] 刘平[1] 张武阳 胡开进[1] ZHANG Yu;XUE Yang;LI Yuan;LIU Ping;ZHANG Wu-yang;HU Kai-jin(State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery,School of Stomatology,the Fourth Military Medical University,Xixan 710032,China)

机构地区：[1]军事口腔医学国家重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医学院口腔外科,陕西西安710032

出　　处：《中国实用口腔科杂志》2020年第2期106-111,共6页Chinese Journal of Practical Stomatology

摘　　要：目的评价不同牙周再生技术预防下颌阻生第三磨牙拔除后邻牙远中牙周缺损的效果。方法计算机检索Embase、Cochrane library、PubMed、Web of Science数据库,查找采用牙周再生技术预防下颌第三磨牙拔除后邻牙远中牙周缺损的英文文献,采用RevMan 5.3和Stata 14.0软件进行Meta分析。结果纳入11篇相关文献,共13组临床随机对照研究,包括生物制剂充填拔牙窝、仅可吸收生物膜覆盖拔牙创、仅骨移植材料充填拔牙窝、骨移植材料充填拔牙窝联合可吸收生物膜覆盖拔牙创4种牙周再生技术。Meta分析结果显示,4种牙周再生技术均能显著减少邻牙远中探诊深度(P <0.05);除仅可吸收生物膜覆盖拔牙创外,其他3种技术均能显著促进邻牙远中临床附着水平的增长(P <0.05);但仅有可吸收生物膜覆盖拔牙创能够显著促进邻牙远中牙槽骨高度的增长(P <0.05)。结论文章分析的4种牙周再生技术均可不同程度的预防下颌阻生第三磨牙拔除后邻牙远中的牙周缺损,但均不能同时促进邻牙远中牙周附着水平增加、探诊深度减少和牙槽骨高度增加。Objective To access the effect of different periodontal regenerative techniques in preventing the periodontal defects distal to mandibular second molars after surgical removal of impacted third molars.Methods English literatures about periodontal regenerative techniques in preventing periodontal defects distal to mandibular second molars after extraction of impacted third molars were searched in Embase,Cochrane library,PubMed and Web of Science.Metaanalysis was performed using RevMan 5.3 and Stata 14.0 software.Results Thirteen randomized clinical trials(RCTs)from eleven literatures were included.Four periodontal regenerative techniques were included:absorbable biological membrane,biological agent filling,bone grafting material alone and bone grafting material combined with absorbable biological membrane.The results showed that all the four techniques could reduce the probing depth of the second molar(P <0.05).Biological agent filling,the use of bone grafting material alone to fill the extraction socket and bone grafting combined with absorbable biological membrane could promote the clinical attachment level(P <0.05).The use of absorbable biological membrane alone could promote the alveolar bone level(P <0.05).Conclusion All the four techniques analyzed in this paper can prevent periodontal defects distal to mandibular second molars after extraction of impacted third molars in varying degrees.But none of them can promote the clinical attachment level,increase the alveolar bone level and decrease the probing depth simultaneously.

关 键 词：下颌阻生第三磨牙 牙周缺损 牙周组织再生技术 META分析 

分 类 号：R78[医药卫生—口腔医学]