牙周基础治疗对2型糖尿病伴慢性牙周炎患者血清生化指标及炎性细胞因子的影响  

Effect of non-surgical periodontal treatment on serum biochemical indexes and inflammatory cytokines in patients with type 2 diabetes mellitus and chronic periodontitis

作　　者：武玮[1] 郝树立[2] 周玉森[1] 梅艳洁[1] 刘振飞[2] WU Wei;HAO Shu-li;ZHOU Yu-sen;MEI Yan-jie;LIU Zhen-fei(Department of Endocrinology,Bozhou People's Hospital,Bozhou,Anhui 236800,China)

机构地区：[1]亳州市人民医院内分泌科,安徽亳州236800 [2]亳州市人民医院口腔科

出　　处：《中华全科医学》2020年第2期249-251,281,共4页Chinese Journal of General Practice

基　　金：安徽省2017公益性技术应用研究联动计划项目(1704f0804037)。

摘　　要：目的通过对2型糖尿病伴慢性牙周炎患者进行牙周基础治疗和常规治疗,分析牙周基础治疗对患者血清中生化指标及炎性细胞因子的影响。方法选择2017年8月-2019年2月亳州市人民医院内分泌及口腔科2型糖尿病伴轻中度慢性牙周炎住院患者共120例,男性58例,女性62例,年龄(56.63±10.96)岁。利用随机数字表法随机分为牙周基础治疗组和常规治疗组,各60例,牙周基础治疗组进行糖尿病常规治疗(包括糖尿病宣教、牙周健康教育、饮食指导、血糖控制)和牙周基础治疗[包括菌斑控制、洁治术和龈下刮治术(根面平整术)、术后洗必泰含漱(3次/d)],常规治疗只进行糖尿病常规治疗。比较治疗前和治疗3个月后2组的血清生化指标(血糖、血脂、糖化血红蛋白比值、血钙、血磷、C-反应蛋白)及炎性细胞因子(TNF-α、IL-1β、IL-6、IL-10)水平。结果治疗前牙周基础治疗组与常规治疗组年龄、性别、BMI、腰围、空腹C肽、牙周炎情况、生化指标及炎症因子水平差异均无统计学意义(均P>0.05);治疗3个月后牙周基础治疗组的血糖、糖化血红蛋白比值、甘油三酯明显低于常规治疗组(均P<0.05);牙周基础治疗组TNF-α、IL-1β水平较常规治疗组明显下降,IL-10水平较常规治疗组明显升高,差异均有统计学意义(均P<0.05)。结论牙周基础治疗可以通过降低血糖、血脂及调节炎性细胞因子水平来改善2型糖尿病合并慢性牙周炎患者的糖脂代谢及炎症状态。Objective To analyze the effect of non-surgical periodontal treatment on biochemical indexes and inflammatory cytokines in serum of patients with type 2 diabetes mellitus and chronic periodontitis through carrying out non-surgical periodontal treatment and routine treatment in patients with type 2 diabetes mellitus and chronic periodontitis. Methods A total of 120 cases of type 2 diabetes mellitus with mild to moderate chronic periodontitis in Bozhou People’s Hospital from August 2017 to February 2019,58 males and 62 females,aged(56.63±10.96) years were collected. According to random number table,patients were divided into the non-surgical periodontal treatment group and the routine treatment group,60 cases each group. The non-surgical periodontal treatment group were received the routine treatment of diabetes,including diabetes education,periodontal health education,diet guidance,blood glucose control,and the non-surgical periodontal treatment,including plaque control,scaling and subgingival scaling(root planning),postoperative chlorhexidine gargle(3 times/d). The routine treatment group were only received the routine treatment of diabetes. The serum biochemical indexes(blood glucose,blood lipid,ratio of glycosylated hemoglobin,blood calcium,blood phosphorus,Creactive protein and inflammatory cytokines(TNF-α,IL-1β,IL-6,IL-10) before and after 3 months of treatment were compared. Results There was no significant difference in age,gender,BMI,waist circumference,fasting C-peptide,periodontitis condition,biochemical indexes and inflammatory factors between the two groups before treatment(all P>0.05). After 3 months of treatment,the blood glucose,glycosylated hemoglobin ratio,triglyceride,the levels of TNF-αand IL-1β in the non-surgical periodontal treatment group were significantly lower than those in the routine treatment group(all P<0.05). The levels of IL-10 in the non-surgical periodontal treatment group were significantly increased compared with those in the routine treatment group(all P<0.05). Conclusio

关 键 词：2型糖尿病 牙周基础治疗 牙周炎 生化指标 炎性细胞因子 

分 类 号：R781.4[医药卫生—口腔医学] R587.1[医药卫生—临床医学]