葡萄糖氧化酶纳米药物介导癌症联合治疗的应用进展  

Advances in the application of glucose oxidase nanodrugs mediated combinational cancer therapy

作　　者：崔志芹[1] 祝忠林 黄德春[1] 钱红亮[1] 于颖[1] 陈维 CUI Zhiqin;ZHU Zhonglin;HUANG Dechun;QIAN Hongliang;YU Ying;CHEN Wei(Department of Pharmaceutical Engineering,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学制药工程系,江苏南京211198

出　　处：《南京工业大学学报（自然科学版）》2020年第2期135-141,共7页Journal of Nanjing Tech University(Natural Science Edition)

基　　金：国家重点研究计划(2017YFD0401301);国家自然科学基金(21878337,21676291);江苏省农业科技自主创新基金(CX(18)3039);东吴科技创新创业领军人才(WC201816)。

摘　　要：纳米药物在癌症疾病的诊断和治疗中展示了重要的作用。葡萄糖氧化酶(GOD)纳米药物催化消耗葡萄糖,同时消耗O2,产生葡萄糖酸和H2O2,阻碍肿瘤的营养供应,降低肿瘤微环境的O2含量和酸度,增强氧化应激等效果。GOD纳米药物联合其他治疗手段可实现对癌症的协同治疗。本文介绍了近年来国内外关于GOD纳米药物联合化药、Fenton试剂和光敏剂等活性分子在协同治疗癌症中的应用所取得的进展,有望提供更优、安全、高效的抗肿瘤策略。Nanomedicines play highly important roles in the diagnosis and treatment of cancer diseases. Glucose oxidase(GOD) nanodrugs catalyze the consumption of glucose with the cost of oxygen, and produce gluconic acid and hydrogen peroxide, by which they hinder the nutritional supplement for tumors, reduce the oxygen content and decrease the acidity of tumor microenvironment to enhance oxidative stress. GOD nanodrugs are widely used by combining with other treatments to realize the synergistic cancer treatment. This paper briefly reviewed the recent progress on the application of GOD nanodrugs combined with active molecules such as chemotherapeutics, Fenton reagents and photosensitizers for combinational cancer therapy, to provide a more safe and efficient anti-tumor strategy in the future.

关 键 词：葡萄糖氧化酶 纳米药物 饥饿治疗 癌症联合治疗 

分 类 号：R730.5[医药卫生—肿瘤]