生长抑素联合泮托拉唑治疗急性胰腺炎的临床观察  

Clinical observation of somatostatin combined with pantoprazole in the treatment of acute pancreatitis

作　　者：杨健民 刘鹏军[2] YANG Jianmin;LIU Pengjun(Emergency Department,Wujin Hospital Affiliated to Jiangsu University,Jiangsu Province,Changzhou 213002,China)

机构地区：[1]江苏大学附属武进医院急诊科,江苏省常州市213002 [2]江苏大学附属武进医院消化科,江苏省常州市213002

出　　处：《临床合理用药杂志》2020年第2期18-20,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察生长抑素联合泮托拉唑治疗急性胰腺炎的临床疗效。方法选择2016年1月-2019年5月江苏大学附属武进医院收治的急性胰腺炎患者60例,按照患者入院时间先后分为观察组与对照组各30例。对照组患者采取常规治疗,观察组患者在其基础上采用生长抑素联合泮托拉唑治疗。对比2组治疗效果、临床相关指标及炎性因子水平。结果经治疗,观察组患者的总有效率为96. 67%明显高于对照组的76. 67%(χ~2=5. 19,P <0. 05)。观察组患者经治疗后,腹痛消失时间、腹腔积液消失时间、白细胞指标正常时间及血淀粉酶水平恢复正常时间均明显短于对照组(P均<0. 05)。经治疗后,观察组患者超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-8(IL-8)水平均明显低于对照组(P均<0. 05)。结论生长抑素联合泮托拉唑治疗急性胰腺炎患者效果明显,可加速患者症状恢复,值得临床应用。Objective To observe the clinical efficacy of somatostatin combined with pantoprazole in the treatment of acute pancreatitis. Methods Selected 60 patients with acute pancreatitis admitted to Wujin Hospital Affiliated to Jiangsu University from January 2016 to May 2019. According to the time of admission,the patients were divided into observation group and control group,each of 30 cases. Patients in the control group were treated conventionally,and patients in the observation group were treated with somatostatin combined with pantoprazole. The treatment effects,clinically relevant indicators and levels of inflammatory factors were compared between the two groups. Results After treatment,the total effective rate of patients in the observation group was 96. 67%,which was significantly higher than 76. 67% in the control group(χ~2= 5. 19,P < 0. 05). After treatment,the time of disappearance of abdominal pain,disappearance of peritoneal effusion,normal time of leukocyte index and normal time of blood amylase level in the observation group were significantly shorter than those of the control group(P < 0. 05). After treatment,the levels of high sensitivity C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),and interleukin-8(IL-8) in the observation group were significantly lower than those in the control group(P <0. 05). Conclusion Somatostatin combined with pantoprazole is effective in treating patients with acute pancreatitis,it can accelerate the recovery of patients’ symptoms and is worthy of clinical application.

关 键 词：生长抑素 泮托拉唑 急性胰腺炎 临床效果 

分 类 号：R576[医药卫生—消化系统]