恐惧应激对胶质瘤影响机制及干预研究进展  

Research progress on the mechanism and intervention of fear stress on glioma

作　　者：李念宣 步星耀[2] LI Nian-xuan;BU Xing-yao(School of basic medicine,Henan university of traditional Chinese medicine,Henan Zhengzhou,450046,China;Henan Provincial People's Hospital,Henan Zhengzhou,450006,China)

机构地区：[1]河南中医药大学基础医学院,河南郑州450046 [2]河南省人民医院神经外科,河南郑州450006

出　　处：《中华养生保健》2020年第4期12-14,共3页CHINESE HEALTH CARE

基　　金：河南省医学科技攻关计划省部共建项目(201601016)。

摘　　要：恐惧心理应激可在一定程度上促进胶质瘤的恶性进展,AMP激活的蛋白激酶与胶质瘤发病机制密切相关.作为一种临床常用抗疟药物,青蒿素具有抗肿瘤活性,可通过AMP激活的蛋白激酶对恐惧应激下的胶质瘤起到干预作用,从而抑制其进展.Fear of psychological stress can promote the malignant progression of glioblastoma to a certain extent,and the amp-activated protein kinase is closely related to the pathogenesis of glioma.Artemisinin,as a commonly used clinical antimalarial drug,has antitumor activity and can act as a targeted intervention against glioblastoma under fear stress through amp-activated protein kinase,thereby inhibiting its progression.

关 键 词：恐惧 胶质瘤 AMP激酶 青蒿素 

分 类 号：R739.41[医药卫生—肿瘤]