扫频光相干生物测量仪在高度近视白内障眼生物测量中的应用  

Application of the swept-source coherence tomography biometer in measurement for cataractous eyes with high myopia

作　　者：李雪婷 陈碧超 李黄恩 王潇 徐艳雪 王勇 Li Xueting;Chen Bichao;Li Huangen;Wang Xiao;Xu Yanxue;Wang Yong(Aier School of Ophthalmology,the Central South University,Changsha 410000,China;Aier Eye Hospital of Wuhan University,Wuhan 430000,China)

机构地区：[1]中南大学爱尔眼科学院,长沙410000 [2]武汉大学附属爱尔眼科医院,武汉430000

出　　处：《中华实验眼科杂志》2020年第2期128-133,共6页Chinese Journal Of Experimental Ophthalmology

基　　金：武汉市医学科研项目(WX17C32、WX17B22);爱尔眼科医院集团科研基金项目(AF1602D2、AM162D08)。

摘　　要：目的评估扫频光相干生物测量仪(OA-2000)在高度近视白内障术前生物测量中的检出率、操作性及一致性。方法采用诊断试验研究方法,纳入2017年10月至2018年10月于武汉大学附属爱尔眼科医院就诊的高度近视白内障患者780例1030眼。采用OA-2000、部分光相干生物测量仪IOLMaster 500和低相干光学测量仪Lenstar-LS900对患者眼球进行生物测量,记录并比较3种仪器眼轴长度(AL)的检出率、信息输入时间、检查时间、从人工晶状体(IOL)计算到打印时间以及总操作时长;分析3种仪器测量的AL、前房深度(ACD)、最小角膜屈光力径线上角膜曲率(Kf)、最大角膜屈光力径线上角膜曲率(Ks)的相关性和一致性。结果OA-2000的AL检出率为94.95%,明显高于IOLMaster 500和Lenstar-LS900的83.98%和83.01%,差异均有统计学意义(χ2=38.171,P<0.001;χ2=46.208,P<0.001)。OA-2000的总操作时长为(109.34±2.22)s,明显短于Lenstar-LS900的(135.64±5.55)s,差异有统计学意义(P<0.05)。OA-2000与IOLMaster 500测量AL、ACD、Kf、Ks的结果均呈强正相关(r=0.999、0.937、0.996、0.996,均P<0.001);OA-2000与Lenstar-LS900测量AL、ACD、Kf、Ks的结果均呈强正相关(r=0.999、0.965、0.995、0.996,均P<0.001)。OA-2000与IOLMaster 500、Lenstar-LS900测量AL的95%一致性界限(LoA)分别为-0.19~0.20 mm和-0.13~0.17 mm,测量ACD的95%LoA分别为-0.23~0.23 mm和-0.18~0.16 mm,测量Kf的95%LoA分别为-0.48~0.47 D和-0.64~0.65 D,测量Ks的95%LoA分别为-0.49~0.47 D和-0.60~0.61 D。结论对于高度近视白内障眼,OA-2000、IOLMaster 500和Lenstar-LS900测量AL、ACD、Kf、Ks有较好的相关性和一致性,同时OA-2000的AL检出率更高,操作更快捷。Objective To evaluate measurement acquisition,operability,and measurement agreement of the OA-2000 in cataract eyes with high myopia.Methods A diagnosis test examined 1030 eyes of 780 high-myopia cataract patients at the Wuhan Aier Eye Hospital from October 2017 to October 2018.The eyes were examined using the OA-2000,the IOLMaster 500 and the Lenstar-LS900 preoperatively.Measurement acquisition was recorded.The total ophthalmic exam,the duration of patient data entry,the actual measurement process,and the time from intraocular lens power calculation to printout were calculated.Ocular biometric parameters,including anterior chamber depth(ACD),axial length(AL),keratometry for the flattest meridian(Kf),and keratometry for the steepest meridian(Ks)were compared among the devices.This study complied with the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Wuhan Aier Eye Hospital(No.2017IRBKY07).Results The OA-2000 was capable of obtaining an AL measurement in 94.95%of the eyes,which was significantly higher than the 83.98%and 83.01%measured by the IOLMaster 500 and Lenstar-LS900,respectively(χ2=38.171,46.208;both at P<0.001).The total ophthalmic exam with the OA-2000 took a significantly shorter time than the Lenstar-LS900([109.34±2.22]s vs.[135.64±5.55]s)(P<0.05).Excellent correlations were found for the AL,ACD,Kf,and Ks measurements between the OA-2000 and the IOLMaster 500(r=0.999,0.937,0.996,0.996;all at P<0.001).Good correlations were also found between the OA-2000 and the Lenstar-LS900(r=0.999,0.965,0.995,0.996;all at P<0.001).The respective 95%limits of agreement of the OA-2000 and IOLMaster 500,and the OA-2000 and Lenstar-LS900 were-0.19 to 0.20 mm and-0.13 to 0.17 mm for AL;-0.23 to 0.23 mm and-0.18 to 0.16 mm for ACD;-0.48 to 0.47 D and-0.64 to 0.65 D for Kf;-0.49 to 0.47 D and-0.60 to 0.61 D for Ks.Conclusions In terms of AL,ACD,Kf and Ks in cataractous eyes with high myopia,the OA-2000,IOLMaster 500,and Lenstar-LS900 show excellent correlation and agreement.The OA-200

关 键 词：高度近视 白内障 生物测量 

分 类 号：R77[医药卫生—眼科]