胰岛素样生长因子系统与角膜疾病关系的研究进展  

Advances in the relationship between insulin-like growth factor system and corneal diseases

作　　者：张静(综述)[1] 周庆军(审校)[1] 谢立信(审校)[1] Zhang Jing;Zhou Qingjun;Xie Lixin(Shandong Eye Institute,Qingdao Eye Hospital Affiliated to Shandong First Medical University,Qingdao 266071,China)

机构地区：[1]山东省眼科研究所,山东第一医科大学附属青岛眼科医院,青岛266071

出　　处：《中华实验眼科杂志》2020年第3期238-242,共5页Chinese Journal Of Experimental Ophthalmology

摘　　要：近年来,对胰岛素样生长因子(IGF)系统研究的越来越深入。除了其经典的调节细胞增生和分化、增强代谢活性、抗细胞凋亡、促细胞生存的作用外,IGF系统在肿瘤生长、细胞自噬、长寿与衰老、氧化应激方面的作用更成为当今研究的热点。针对IGF信号通路中相应靶点的药物也逐渐进入试验阶段。本文简要概括了IGFs及其主要信号通路在生长发育和疾病发生中的重要作用,对该系统成分与角膜疾病关系及应用现状进行综述,探讨其存在的问题和前景。Recently,an increasing number of studies on the insulin-like growth factor(IGF)system have been conducted.In addition to its well-known regulation of cell proliferation and differentiation,enhanced metabolic activity,anti-apoptosis,and promotion of cell survival,the role of IGF in tumor growth,autophagy,longevity and aging,and oxidative stress has become a hot spot.Drugs targeting IGF signaling pathways are also progressing into the clinical experimental phase.This article summarized the important role of IGFs and its major signaling pathways in the growth and development,their relationship with the corneal diseases,and discussed the related problems and prospects.

关 键 词：胰岛素样生长因子-1 胰岛素样生长因子-1受体 胰岛素样生长因子结合蛋白 胰岛素受体底物 角膜疾病 

分 类 号：R77[医药卫生—眼科] R5[医药卫生—临床医学]