Nef蛋白与HIV-1的潜伏感染  

Nef protein and latent infection of HIV-1

作　　者：万智凯 况煌 周志锋 罗瑞 邹薇[2] WAN Zhikai;KUANG Huang;ZHOU Zhifeng;LUO Rui;ZOU Wei(School of Medicine,Nanchang University,Nanchang 330000,China;The First Affiliated Hospi tal of Nanchang University,Nanchang 330006)

机构地区：[1]南昌大学医学院,南昌330000 [2]南昌大学第一附属医院,南昌330006

出　　处：《中国艾滋病性病》2019年第12期1299-1303,共5页Chinese Journal of Aids & STD

基　　金：国家自然科学基金(81660279,81701629);江西省科技厅(20161ACB21016,20171BCB23088,20181ACH80002);留学回国人员启动基金(2015060020102070)。

摘　　要：1型艾滋病病毒(HIV-1)感染可引起严重的全身免疫系统损害最终导致患者死亡。抗病毒治疗(ART)可有效抑制病毒复制,从而提高HIV-1感染者的存活率,但长期ART并不能清除HIV-1潜伏库。一旦停止抗病毒治疗,病毒再度复制将不可避免地发生。作为HIV-1表达的早期蛋白之一,Nef可经多种途径调节宿主细胞的功能状态及病毒自身复制状况,从而可能影响HIV-1的潜伏感染。本文就Nef蛋白影响HIV-1潜伏感染的可能机制和途径做一综述,为HIV-1防治提供新的思路和线索。Human immunodeficiency virus-1(HIV-1)infection causes severe damage to immune system and ultimately leads to death of infected patients.Anti-retroviral therapy(ART)can effectively inhibit viral replication and increase the survival rate of infected patients.However,a long-term ART is unable to clear the latent reservoir of infection.Once antiviral therapy stops,viral replication will inevitably reoccur.As one of the early proteins expressed by HIV-1,Nef protein is capable of regulating the functional status of host cells and viral replication through various pathways,thus it may affect HIV-1 latency.This review will focus on the potential mechanisms and pathways that Nef protein may exploit to affect HIV-1 latency,which provides new insights and clues for the prevention and treatment of HIV-1 infection.

关 键 词：NEF蛋白 1型艾滋病病毒潜伏 细胞表面分子 AKT NF-KB 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]