成人种痘样水疱病样淋巴瘤一例并文献复习  

Adult hydroa vacciniforme-like lymphoma:a case report and literature review

作　　者：杨佼[1] 徐晨琛 崔炳南[1] YANG Jiao;XU Chenchen;CUI Bingnan(Department of Dermatology,Guang anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院皮肤科,北京100053

出　　处：《中国麻风皮肤病杂志》2020年第3期165-167,共3页China Journal of Leprosy and Skin Diseases

摘　　要：本文报道1例种痘样水疱病样淋巴瘤并对WHO最新分类、EBV感染相关发病机制、鉴别诊断及治疗方面的相关文献进行复习。患者,男,38岁。全身反复皮疹30年,加重1年,患者病程中伴有发热,皮损预后遗留凹陷性瘢痕。血清EB病毒抗体IgG阳性。皮损组织病理示:真皮全层及皮下脂肪小叶内大量淋巴细胞浸润。免疫组化染色示:CD2(+++),CD3(++),CD8(++),TIA-1(++),CD56(少量+),CD20(灶状+),Ki-67>30%。EB病毒原位杂交:阳性。诊断:种痘样水疱病样淋巴瘤。A case of hydroa vacciniforme-like lymphoma was reported and the literature of the latest WHO classification,EBV infection-related pathogenesis,differential diagnosis and treatment were reviewed.A 38-year-old male presented with relapsed generalized lesions and fever for 30 years and aggravated for 1 year.Pitted scars were left after lesions relieved.The patient was positive for EB antibodies(IgG).Histopathological examination showed dense infiltration of lymphocytes in the whole dermis and subcutaneous tissue.Immunohistochemistory showed CD2(+++),CD3(++),CD8(++),TIA-1(++),CD56(+),CD20(focal+),Ki-67>30%,EBER(+).The diagnosis of hydroa vacciniforme-like lymphoma was made.

关 键 词：种痘样水疱病样淋巴瘤 种痘样水疱病样淋巴增生性疾病 EB病毒 

分 类 号：R739.5[医药卫生—肿瘤]