ARID5B基因rsl0821936多态位点与儿童急性淋巴细胞白血病易感关联的系统评价和meta分析  

Relationship between ARID5B gene rs10821936 polymorphism and risk of childhood acute lymphoblastic leukemia: a systematic and meta-analysis

作　　者：陈先睿[1] 温红[1] 黄建琪[1] 郭碧赟[1] 白海涛[1] 吴谨准[1] Chen Xianrui;Wen Hong;Huang Jianqi;Guo Biyun;Bai Haitao;Wu Jinzhun(Department of Pediatrics,the First Affiliated Hospital of Xiamen University,Xiamen 361000,China)

机构地区：[1]厦门大学附属第一医院儿科,福建厦门361000

出　　处：《临床荟萃》2020年第3期197-205,共9页Clinical Focus

基　　金：厦门市科学技术局科技惠民项目闽南地区急性淋巴细胞白血病患儿基因多态性与甲氨蝶呤治疗相关性研究(3502Z20164007)。

摘　　要：目的评价ARID5B基因rsl0821936多态位点与儿童急性淋巴细胞白血病(ALL)易感的关联。方法计算机检索Cochrane图书馆、PubMed、EMCC、OVID、中国知网、维普中文期刊数据库和万方数据库上的中英文相关文献,检索时间均为建库至2019年03月。2名研究者独立提取资料数据和评价纳入文献,并进行文献偏倚风险评价。采用RevMan5.3和Stata 12.0软件,分别以风险等位基因频率、隐性、显性、共显性和等位基因模型对基因多态性与儿童ALL易感的关联进行meta分析。结果 15篇文献共19个研究纳入meta分析,病例组11 542例,对照组30 205例。所有模型meta分析结果显示,风险等位基因频率(OR=1.77, 95%CI:1.70-1.85)、隐性(OR=1.94, 95%CI:1.61-2.23)、显性(OR=1.92, 95%CI:1.75-2.12)、共显性(OR=2.65, 95%CI:2.31-3.03;OR=1.71, 95%CI:1.54-1.89)及等位基因模型(OR=1.67, 95%CI:1.49-1.87)与儿童ALL易感风险均存在关联。按照种族进行分组分析显示,中国人群的显性模型(CC+TC vs TT)(OR=2.16,95%CI:0.93-5.00)与儿童ALL易感性无关,其余各基因模型亚组分析与增加儿童ALL发生风险仍具有关联。结论 ARID5B基因rsl0821936多态位点与增加儿童ALL易感风险可能存在关联,但与中国儿童ALL人群的易感相关性仍有待进一步研究。Objective To explore the association between ARID5B gene rs10821936 polymorphism and the risk of childhood acute lymphoblastic leukemia(ALL).Methods The cochrane library, PubMed, EMCC, OVID,CNKI, VIP and Wanfang digital knowledge service platform were searched for relevant articles published in English and Chinese up to March 2019.Two researchers independently extracted data and assessed the literature.Literature bias risk assessment was also conducted.RevMan5.3 and Stata 12.0 software were used to analyze the association between gene polymorphism and the risk of childhood ALL with risk allele frequency, recessive, dominant, codominant and allele models, respectively.Results A total of 19 studies in 15 references were included in the meta-analysis, including 11 542 cases in case group and 30 205 cases in control group. Meta-analysis results of all models showed that risk allele frequency(OR=1.77, 95%CI:1.70-1.85), recessive(OR=1.94, 95%CI:1.61-2.23), dominant(OR=1.92, 95%CI: 1.75-2.12), codominant(OR=2.65, 95%CI:2.31-3.03), and allele model(OR=1.67, 95%CI:1.49-1.87) were associated withthe risk of childhood ALL. According to the group analysis by race, the dominance model(CC+TC vs TT) of Chinese population(OR=2.16, 95%CI:0.93-5.00) was not correlated with the susceptibility of childhood ALL, while the subgroup analysis of other gene models was still correlated with the increased risk of ALL in children.Conclusion ARID5 B gene SNPs rsl0821936 may be associated with an increased risk of childhood ALL, but the susceptibility correlation with ALL in Chinese children remains further study.

关 键 词：前体细胞淋巴母细胞白血病淋巴瘤 ARID5B rs10821936 基因多态性 META分析 系统评价 

分 类 号：R733.7[医药卫生—肿瘤]