血清Cla-1、MK和Gal-1水平诊断桥本甲状腺炎合并乳头状甲状腺癌的临床价值  

Clinical value of serum Cla-1,MK and Gal-1 levels in diagnosis of Hashimoto thyroiditis with papillary thyroid cancer

作　　者：唐志金 沈华 于海文 Tang Zhijin;Shen Hua;Yu Haiwen(Department of General Surgery,Shanghai Nanxiang Hospital,Shanghai 201802,China)

机构地区：[1]上海市嘉定区南翔医院普外科,上海201802

出　　处：《临床荟萃》2020年第3期255-259,共5页Clinical Focus

摘　　要：目的血清紧密连接蛋白1(Cla-1)、中期因子(MK)和半乳糖血凝素1(Gal-1)水平在诊断桥本甲状腺炎(HT)合并乳头状甲状腺癌(PTC)的临床价值。方法选择2018年1月至2019年12月在我院诊治的HT合并PTC患者107例,为HT合并PTC组。选择同期在我院就诊HT患者65例和健康体检者30例,分别为HT组和健康对照组。观察各组血清Cla-1、MK和Gal-1水平的变化,HT合并PTC患者血清Cla-1、MK和Gal-1水平与HT分期,TNM分期及其各个指标的相互关系,及其在诊断HT患者合并PTC的诊断效能。结果HT合并PTC组血清Cla-1、MK和Gal-1水平明显高于HT组和健康对照组(P<0.01),HT组血清Gal-1水平明显高于健康对照组(P<0.01)。HT合并PTC患者血清Cla-1、MK和Gal-1水平素随着HT分期和TNM分期升高而出现明显的升高(P<0.01)。HT合并PTC患者血清Cla-1与MK和Gal-1水平呈正相关,而血清MK与Gal-1呈正相关。血清Cla-1、MK和Gal-1水平在诊断HT合并PTC具有较高的灵敏度和特异度,联合检测的灵敏度为88.8%,特异度为90.8%,AUC为0.941明显高于Cla-1,MK、Gal-1。结论Cla-1、MK和Gal-1参与了HT合并PTC的发生发展,在预测HT患者发生PTC具有较高的诊断效能。Objective To observe the clinical value of serum claudin-1(Cla-1),midkine(MK),and galectin-1(Gal-1)levels in the diagnosis of Hashimoto thyroiditis(HT)with papillary thyroid cancer(PTC).Methods Totally 107 HT patients with PTC in our hospital from January 2018 to December 2019 were selected as HT with PTC group,meanwhile,65 HT patients and 30 healthy people examined in our hospital during the same period were selected as the HT group and the healthy control group,respectively.The serum Cla-1,MK and Gal-1 levels were observed in each group.And the correlation among serum Cla-1,MK and Gal-1 levels in HT patients with PTC,HT stage,and TNM stage were also observed,as well as its diagnostic value for HT with PTC.Results The serum Cla-1,MK and Gal-1 levels in HT with PTC group were significantly higher than those in HT group and healthy control group(P<0.01).The serum Gal-1 level in HT group was obviously higher than that in health control group(P<0.01).The levels of serum Cla-1,MK and Gal-1 in HT patients with PTC increased significantly with the increase of HT stage and TNM stage(P<0.01).The serum Cla-1 level was positively correlated with MK and Gal-1 levels in HT patients with PTC,and the serum MK was positively correlated with Gal-1.The serum Cla-1,MK and Gal-1 levels had higher sensitivity and specificity in the diagnosis of HT with PTC.The sensitivity and specificity of the combined detection were 88.8%and 90.8%,respectively.And the AUC was 0.941,which was significantly higher than that measured by the detection of Cla-1,MK and Gal-1,respectively.Conclusion The Cla-1,MK and Gal-1 are involved in the development of HT with PTC,which havehigher diagnostic efficacy in predicting the occurrence of PTC in HT patients.

关 键 词：甲状腺肿瘤 紧密连接蛋白质类 血凝素类 

分 类 号：R736.1[医药卫生—肿瘤]