血小板介导肿瘤细胞生长和转移的机制研究进展  

Research Progress in Mechanism of Platelet-mediated Tumor Cell Growth and Metastasis

作　　者：董超男 翟文萍 王雪野[2] DONG Chaonan;ZHAI Wenping;WANG Xueye(Changchun University of Chinese Medicine,Changchun 130117,China;Drug Clinical Trial Institute,Jilin Province People′s Hospital,Changchun 130021,China)

机构地区：[1]长春中医药大学,长春130117 [2]吉林省人民医院药物临床试验机构,长春130021

出　　处：《医学综述》2020年第4期695-699,共5页Medical Recapitulate

摘　　要：血小板是骨髓中成熟巨核细胞脱落的细胞质片段,其基本功能是参与凝血、免疫反应及组织修复、重建等过程。近年来发现,血小板在肿瘤的形成和发展中起着至关重要的作用,其可促进肿瘤细胞的生长、转移,增强侵袭能力,协助逃避免疫系统监视,促进血管生成及血栓形成。同时肿瘤细胞也可通过直接接触或间接作用使血小板活化,扰乱凝血系统,进一步增强肿瘤细胞的转移。因此,抗血小板可能成为抗肿瘤协同治疗的潜在靶点。Platelets are cytoplasmic fragments shed by mature megakaryocytes in bone marrow. Their basic functions are participating in coagulation,immune response,tissue repair and reconstruction. Recent studies have shown that platelets also play a crucial role in the formation and development of tumors. Platelets can promote the growth and metastasis of tumor cells,enhance the invasiveness,help evade the surveillance of the immune system,and promote angiogenesis and thrombosis.At the same time,tumor cells can also activate platelets through direct contact or indirect action,disrupting the coagulation system and further enhancing the metastasis of tumor cells. Therefore,antiplatelet may be a potential target for synergistic antitumor therapy.

关 键 词：血小板 肿瘤 肿瘤转移 血管生成 血小板活化 

分 类 号：R730.2[医药卫生—肿瘤]