中药有效成分在溃疡性结肠炎相关信号转导通路中的作用研究进展  

Research Advances in Role of Active Ingredients of Traditional Chinese Medicines in Ulcerative Colitis-related Signal Transduction Pathway

作　　者：张旖晴[1] 魏玮[1] 苏晓兰[1] 程遥[1] 王欣[1] 许爱丽 杨洋[1] ZHANG Yiqing;WEI Wei;SU Xiaolan;CHENG Yao;WANG Xin;XU Aili;YANG Yang(Beijing Key Laboratory of TCM Diagnosis and Treatment of Functional Gastrointestinal Diseases/Department of Spleen and Stomach Diseases,Wangjing Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100102,China)

机构地区：[1]功能性胃肠病中医诊治北京市重点实验室中国中医科学院望京医院脾胃病科,北京100102

出　　处：《医学综述》2020年第4期743-747,共5页Medical Recapitulate

基　　金：中国中医科学院基本科研业务费自主选题项目(ZZ11-083)。

摘　　要：溃疡性结肠炎(UC)是一种常见的肠道炎症性疾病,目前尚缺乏理想的治疗方案。中药具有长期服用不良反应小、多系统、多靶点调控的优势,在治疗慢性、复杂性疾病方面具有显著的优势。近年来,中药治疗已成为UC替代治疗和补充治疗的常见方式。中医药治疗UC涉及多种信号转导通路,对常见中药成分所涉及信号转导通路进行研究,有助于深入了解中药有效成分治疗UC的作用机制,为开发新的药物及治疗方案提供思路。Ulcerative colitis( UC) is a common intestinal inflammatory disease,and there is still no ideal treatment now. Traditional Chinese medicine has the advantages of long-term effects but with few adverse effects,multi-system and multi-target regulation,showing significant advantages in the treatment of chronic and complex diseases. In recent years,TCM treatment has become a common replacement and supplementary treatment to treat UCThe traditional Chinese medicine treatment involves a variety of signal transduction pathways,and studying the signal transduction pathways involved in common traditional Chinese medicine ingredients can help to understand the mechanism of the active TCM ingredients in the treatment of UC,and provide ideas for the development of new drugs and treatments.

关 键 词：溃疡性结肠炎 信号转导通路 中药 有效成分 

分 类 号：R573.1[医药卫生—消化系统]