双黄连口服液辅助治疗儿童口腔溃疡心脾积热证45例临床观察  

Clinical observation on Shuanghuanglian Koufuye(双黄连口服液) in adjuvant treatment of 45 cases of oral ulcer in children with heart and spleen heat accumulation syndrome

作　　者：丁盛 韩红卫 徐文雄 DING Sheng;HAN Hongwei;XU Wenxiong(Department of Stomatology,Wenzhou Integrated Traditional Chinese and Western Medicine Hospital,Wenzhou,Zhejiang,325000,China;Department of Pediatrics,Women and Children’s Hospital of Wenzhou The People’s Hospital,Wenzhou,Zhejiang,325000,China)

机构地区：[1]温州市中西医结合医院口腔科,浙江温州325000 [2]温州市人民医院妇女儿童医院儿科,浙江温州325000

出　　处：《中医儿科杂志》2020年第1期69-72,共4页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察双黄连口服液辅助治疗儿童口腔溃疡心脾积热证的临床疗效。方法选取2016年4月至2018年4月温州市中西医结合医院口腔科收治的90例口腔溃疡心脾积热证患儿,按照随机数字表法分为对照组和治疗组,各45例。2组均给予复合维生素B片、维生素C片及溃疡面清洁等常规治疗,对照组在常规治疗的基础上予康复新液口服,治疗组在对照组治疗方法的基础上予双黄连口服液口服,2组均7 d为1个疗程,1个疗程后观察临床疗效。结果治疗前,2组血清炎性因子白细胞介素-2(IL-2)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平比较,差异均无统计学意义(P>0.05),具有可比性。治疗后,2组IL-2水平显著升高,IL-6、TNF-α水平显著下降,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高或下降更显著(P<0.05)。治疗前,2组视觉模拟评分法(VAS)评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组VAS评分显著降低(P<0.05),与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。治疗组溃疡愈合时间显著短于对照组,差异有统计学意义(P<0.05)。治疗组总有效率为97.78%,对照组为80.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患儿均无任何药物相关不良反应,且肝肾功能检查均正常。结论双黄连口服液辅助治疗儿童口腔溃疡心脾积热证,能明显减轻患儿炎性反应,缓解疼痛,促进溃疡愈合,临床疗效显著,且安全性高,值得临床推广应用。Objective To observe the clinical efficacy of Shuanghuanglian Koufuye(双黄连口服液) in adjuvant treatment of oral ulcer in children with heart and spleen heat accumulation syndrome.Methods Ninety cases of oral ulcer in children with heart and spleen heat accumulation syndrome admitted to stomatology department of Wenzhou Integrated Traditional Chinese and Western Medicine Hospital from April 2016 to April 2018 were divided into control group and treatment group according to random number table method, with 45 cases in each.Both groups were given routine treatment such as compound vitamin B tablets,vitamin C tablets and ulcer surface cleansing,on this basis,the control group was given Kangfuxinye(康复新液) orally,and the treatment group was given Shuanghuanglian Koufuye based on the therapeutic method of the control group.Seven days constituted 1 course of treatment for both groups,and the clinical efficacy of the 2 groups was observed after 1 course of treatment.Results Before treatment,there were no statistical significant differences in levels of serum inflammatory factor interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor(TNF-α) between the two groups(P>0.05),and they were comparable.After treatment,the levels of IL-2 in the two groups significantly increased,while the levels of IL-6 and TNF-α significantly decreased,the difference was statistically significantly compared with the same group before treatment(P<0.05), moreover,the treatment group increased or decreased more significantly(P<0.05).Before treatment,the difference was not statistically significant in visual analogue score(VAS) between the two groups(P>0.05),and they were comparable.After treatment,the VAS of the two groups decreased significantly(P<0.05),the difference was statistically significantly compared with the same group before treatment(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).The ulcer healing time of the treatment group was significantly shorter than that of the control group,and the

关 键 词：口腔溃疡 儿童 心脾积热证 双黄连口服液 临床观察 

分 类 号：R781.59[医药卫生—口腔医学]