老年阿尔茨海默病患者血清Lp-PLA2,NLRP3水平表达及其与认知功能损害的相关性  

Expression of Serum Lp-PLA2 and NLRP3 in Elderly Patients with Alzheimer's Disease and Its Relationship with Cognitive Impairment

作　　者：孙祝平[1] 陈红英[1] 陈思路[1] SUN Zhu-ping;CHEN Hong-ying;CHEN Si-lu(Department of Psychiatry,Shanghai Changning District Mental Health Center,Shanghai 200335,China)

机构地区：[1]上海市长宁区精神卫生中心精神科,上海200335

出　　处：《现代检验医学杂志》2020年第1期49-52,共4页Journal of Modern Laboratory Medicine

基　　金：上海市长宁区卫生和计划生育委员会(编号:20163003)。

摘　　要：目的分析阿尔茨海默病(AD)患者血清脂蛋白相关磷脂酶A2(lipoprotein related phospholipase,Lp-PLA2),NOD样受体家族蛋白3(nod-like receptor family protein 3,NLRP3)的表达,及其与认知功能损害的关系。方法测定110例AD患者(AD组)及50例健康体检者(对照组)血清中Lp-PLA2和NLRP3表达水平,并采用蒙特利尔认知评估量表(MoCA)、简易精神状态量表(MMSE)和临床痴呆量表(CDR)评估患者认知能力。根据CDR评分将AD组患者分为轻度AD组(n=61)和中重度AD组(n=49)。分析各组血清Lp-PLA2和NLRP3表达水平与认知功能损害的相关性。结果与轻度AD组比较,中重度AD组MoCA和MMSE评分均明显下降,CDR评分明显升高(t=10.21,9.17和7.96,均P<0.05)。与对照组比较,轻度、中重度AD组血清Lp-PLA2,NLRP3水平均明显升高(P<0.05)。与轻度AD组比较,中重度AD组血清Lp-PLA2,NLRP3水平亦显著升高(P<0.05)。Pearson线性相关分析显示,AD患者血清Lp-PLA2,NLRP3水平与MoCA,MMSE评分均呈显著正相关,与CDR评分呈显著负相关(P<0.05)。结论AD患者血清Lp-PLA2,NLRP3表达异常升高,与认知功能损害密切相关,可作为反映认知功能损害程度的早期血清学标志物。Objective To investigate the expression of serum lipoprotein related phospholipase A2(Lp-PLA2)and NOD-like receptor family protein 3(NLRP3)in elderly patients with Alzheimer's disease(AD),and analyze its relationship with cognitive impairment.Methods The expression levels of serum Lp-PLA2 and NLRP3 in 110 patients with AD(AD group)and 50 healthy subjects(control group)were measured,and the cognitive ability was evaluated by the Montreal cognitive assessment scale(MoCA),simple mental state scale(MMSE)and clinical dementia scale(CDR).According to the CDR score,patients in the AD group were divided into mild AD group(n=61)and moderate and severe AD group(n=49).The correlation between serum Lp-PLA2 and NLRP3 expression and cognitive impairment was analyzed.Results Compared with the mild AD group,MoCA and MMSE scores in the moderate and severe AD group were significantly decreased,and CDR scores were significantly increased(t=10.21,9.17 and 7.96,all P<0.05).Compared with the control group,serum Lp-PLA2 and NLRP3 levels in mild,moderate and severe AD groups were significantly increased(P<0.05).Serum Lp-PLA2 and NLRP3 levels were also significantly increased in the moderate to severe AD group compared with the mild AD group(P<0.05).Pearson linear correlation analysis showed that serum Lp-PLA2 and NLRP3 levels were significantly positively correlated with MoCA and MMSE scores and negatively correlated with CDR scores(P<0.05),Conclusion The levels of serum Lp-PLA2 and NLRP3 in patients with AD was overexpressed,which was closely related to cognitive impairment and can be used as early serological markers to reflect the degree of cognitive impairment.

关 键 词：阿尔茨海默病 脂蛋白相关磷脂酶A2 NOD样受体家族蛋白3 认知功能 相关 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R392.11[医药卫生—临床医学]