羟苯磺酸钙致患者血清肌酐水平波动1例并文献复习  

Fluctuation of serum creatinine level in patients with calcium hydroxybenzenesulfonate:A case report and literature review

作　　者：王新[1] 张泉 林雯[1] WANG Xin;ZHANG Quan;LIN Wen(Department of Clinical Laboratory,Huangshi Aikang Hospital in Hubei Province,Huangshi435000,China)

机构地区：[1]湖北省黄石市爱康医院检验科,湖北黄石435000

出　　处：《中国现代医生》2020年第3期163-165,共3页China Modern Doctor

摘　　要：肌氨酸氧化酶法是国内使用最广泛的肌酐检测方法,具有特异性强、线性范围宽、抗干扰力强等优点,但是该反应偶联的Trinder反应易受还原性物质的负干扰。羟苯磺酸钙类药物对于肌氨酸氧化酶法肌酐的检测普遍存在负干扰,尤其对肾功能较差的患者更为明显。本文通过对我院收治的1例肾移植术后患者的临床表现、肌酐及肾功能变化进行分析并查阅相关文献,进一步探讨羟苯磺酸钙类药物对肌酐检测的干扰,通过分析对提高临床医生、实验室人员以及患者对羟苯磺酸钙的认识,具有重要的警示意义。The sarcosine oxidase method is the most widely used creatinine detection method in China.It has the advantages of strong specificity,wide linear range and strong anti-interference ability.However,the Trinder reaction coupled with this reaction is susceptible to negative interference of reducing substances.Calcium hydroxybenzenesulfonate has a general negative interference with the detection of creatinine by creatinine oxidase method,especially for patients with poor renal function.This article analyzes the clinical manifestations,creatinine and renal function changes of a patient after renal transplantation in our hospital and consults relevant literature,to further investigate the interference of calcium hydroxybenzenesulfonate on creatinine detection.It is of great warning significance for improving the understanding of clinicians,laboratory personnel and patients’knowledge of calcium hydroxybenzenesulfonate.Doctors,laboratory personnel,and patients with knowledge of calcium dobesilate have important warnings.

关 键 词：羟苯磺酸钙 肌酐 肌氨酸氧化酶法 负干扰 

分 类 号：R961[医药卫生—药理学] R446.11[医药卫生—药学]