MCP-1、VEGF在人脑胶质瘤中的表达及其相关性  

Correlation between the Expression of Monocyte Chemoattractantprotein-1 and Vascular Endothelial Cell Growth Factor in Glioma Tissue

作　　者：王宏宇 韦焘 王进昆[3] 杨智勇[3] 王伟民[3] 丁鹏[3] WANG Hong-yu;WEI Tao;WANG Jin-kun;YANG Zhi-yong;WANG Wei-min;DING Peng(Dept.of Neurosurgery,Jilin Provincial Brain Hospital,Siping Jilin 136000;Kunming Medical University Library,Kunming Yunnan 650500;Dept.of Neurosurgery,The First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]吉林省神经精神病医院神经外科,吉林四平136000 [2]昆明医科大学图书馆,云南昆明650500 [3]昆明医科大学第一附属医院神经外科,云南昆明650032

出　　处：《昆明医科大学学报》2020年第1期26-30,共5页Journal of Kunming Medical University

基　　金：云南省自然科学基金资助项目(2010CD157);昆明医科大学“十三五”校级学科建设基金资助项目(J1301826)。

摘　　要：目的检测MCP-1、VEGF蛋白在人脑胶质瘤中表达、评估两者相互间的关系。方法采用免疫组化法分别检测不同病理级别胶质瘤组织中MCP-1、VEGF的阳性表达率,分析MCP-1和VEGF之间的关系。结果在人脑胶质瘤组织中MCP-l、VEGF阳性表达随病理级别增高而阳性表达增强(P<0.05),且呈正相关(P<0.05)。结论MCP-1、VEGF在胶质瘤的发生、发展中具有一定促进作用,联合检测MCP-1和VEGF在一定程度上可为临床胶质瘤患者判断恶性程度及治疗提供思路。Objective To evaluate the expression of MCP-1,VEGF in glioma,and their correlations.Methods The average positive expression rate of MCP-1,VEGF in glioma tissue of different grades were detected with immunohistochemical staining,and the correlation between MCP-1,VEGF were explored.Results The positive expression rate of MCP-1,VEGF were significantly different(P<0.05),The higher the grade of glioma,the more obvious level the positive expression rate of MCP-1 and VEGF.Conclusions MCP-1 and VEGF can promote the occurrence and development of glioma.Combined detection of MCP-1 and VEGF can provide a way for clinical glioma patients to judge the malignant degree and treatment.

关 键 词：MCP-1 VEGF 胶质瘤 血管生成 免疫组化 

分 类 号：R739.41[医药卫生—肿瘤]