血管内介入疗法治疗急性缺血性脑卒中的疗效及其对纤维蛋白原、同型半胱氨酸水平和预后的影响  

Effect of intravascular intervention therapy on fibrinogen,homocysteine and prognosis of acute ischemic stroke

作　　者：宋贺[1] 张金峰[1] 唐蕊[2] 左书浩[1] 苏现辉[1] SONG He;ZHANG Jin-feng;TANG Rui;ZUO Shu-hao;SU Xian-hui(Department of Neurosurgery,the First Hospital of Shijiazhuang,Hebei Province,Shijiazhuang 050011,China;Department of Neurology,the First Hospital of Shijiazhuang,Hebei Province,Shijiazhuang 050011,China)

机构地区：[1]河北省石家庄市第一医院神经外科,河北石家庄050011 [2]河北省石家庄市第一医院神经内科,河北石家庄050011

出　　处：《河北医科大学学报》2020年第3期298-301,共4页Journal of Hebei Medical University

基　　金：石家庄市科学技术研究与发展指导计划(171792083)。

摘　　要：目的探究血管内介入疗法治疗急性缺血性脑卒中的疗效及其对纤维蛋白原(fibrinogen,FIB)、同型半胱氨酸(homocysteine,HCY)水平和预后的影响。方法选取行血管内介入疗法治疗的急性缺血性脑卒中患者60例为观察组,接受药物静脉溶栓治疗的急性缺血性脑卒中患者60例为对照组。于溶栓前、溶栓后即刻、溶栓10 d后比较2组美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分和血管再通评分,FIB和HCY水平,格拉斯哥预后(Glasgow Outcome Scale,GOS)评分。结果2组NIHSS评分、FIB和HCY水平呈降低趋势,血管再通评分、GOS评分呈升高趋势,观察组NIHSS评分、FIB和HCY水平降低幅度大于对照组,血管再通评分、GOS评分升高幅度大于对照组,组间、时点间、组间·时点间交互作用差异有统计学意义(P<0.05或P<0.01)。结论血管内介入治疗可改善急性缺血性脑卒中患者的神经功能缺损症状,提升血管再通率,降低FIB、HCY水平,有利于改善预后。Objective To explore the effect of endovascular intervention therapy on fibrinogen(FIB),homocysteine(HCY)level and prognosis of acute ischemic stroke.Methods A total of 60 patients with acute ischemic stroke receiving intravascular interventional therapy were selected as the observation group,and 60 patients receiving intravenous thrombolysis were selected as the control group.The National Institute of Health stroke scale(NIHSS)score,recanalization score,FIB and HCY level,and Glasgow Outcome scale(GOS)score were compared between two groups before,immediately after and 10 d after thrombolysis.Results NIHSS score,FIB and HCY levels in the 2 groups showed a trend of decrease,recanalization score,GOS score showed a trend of increase,observation group NIHSS score,FIB and HCY levels to reduce the amplitude was greater than the control group,recanalization rate high,GOS score was greater than the control group,between groups,between point,between groups,interaction between point difference was statistically significant(P<0.05 or P<0.01).Conclusion Intravascular interventional therapy can improve the symptoms of neurological defects in patients with acute ischemic stroke,improve the vascular recanalization rate,reduce the levels of FIB and HCY,and improve the prognosis.

关 键 词：卒中 血管内介入治疗 静脉溶栓 

分 类 号：R743[医药卫生—神经病学与精神病学]